Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Florence Charlieux, Hassan Abdoul‐carime. Processes Induced by Electrons at Sub‐Ionization Energies Studied by the Correlated Ions‐(Ions/Neutrals) Mass Spectrometry. ChemPhysChem, 2023, 24 (8), pp.e202200722. ⟨10.1002/cphc.202200722⟩. ⟨hal-03960242⟩
  • Mario Alcocer-Ávila, Caterina Monini, Micaela Cunha, Étienne Testa, MichaĂ«l Beuve. Formalism of the NanOx biophysical model for radiotherapy applications. Frontiers in Physics, 2023, 11, pp.1011062. ⟨10.3389/fphy.2023.1011062⟩. ⟨hal-04518897⟩
  • H Abdoul-Carime, F Mounier, F Charlieux, H AndrĂ©. Correlated ion-(ion/neutral) time of flight mass spectrometer. Review of Scientific Instruments, 2023, 94 (4), pp.045104. ⟨10.1063/5.0141540⟩. ⟨hal-04088616⟩
  • Oreste Allegrini. CaractĂ©risation de dĂ©tecteurs pour des systĂšmes de monitorage des faisceaux d'ions en hadronthĂ©rapie. Physique MĂ©dicale [physics.med-ph]. UniversitĂ© Claude Bernard - Lyon I, 2022. Français. ⟨NNT : 2022LYO10110⟩. ⟨tel-04458930⟩
  • Feriel Khellaf, Nils Krah, Jean Michel LĂ©tang, Simon Rit. Projection deconvolution for proton CT using the spatially variant path uncertainty. IEEE Transactions on Radiation and Plasma Medical Sciences, 2022, 6 (8), pp.847-858. ⟨10.1109/TRPMS.2022.3167334⟩. ⟨hal-03656408⟩
  • VerĂłnica BelĂ©n Tessaro. Energy deposition of ionizing radiation in biological systems of interest : study of hadron track structure and dosimetric application for hadrontherapy. Physics [physics]. UniversitĂ© Claude Bernard - Lyon I; Universidad nacional de Rosario (Argentine), 2022. Español. ⟨NNT : 2022LYO10017⟩. ⟨tel-04023636⟩
  • Delphine Brichart-Vernos. Nouvelles gĂ©nĂ©rations de nanoparticules mĂ©talliques permettant d’amplifier la rĂ©ponse Ă  la radiothĂ©rapie des cancers radiorĂ©sistants et invasifs. IngĂ©nierie biomĂ©dicale. UniversitĂ© de Lyon, 2022. Français. ⟨NNT : 2022LYSE1139⟩. ⟨tel-04190168⟩
  • Yasmine Ali, Caterina Monini, Etienne Russeil, Jean Michel LĂ©tang, Etienne Testa, et al.. Estimate of the Biological Dose in Hadrontherapy Using GATE. Cancers, 2022, 14 (7), pp.1667. ⟨10.3390/cancers14071667⟩. ⟨hal-03622514⟩
  • Hassan Abdoul-Carime, Guillaume Thiam, Franck Rabilloud, Florence Charlieux, Janina Kopyra. Chemistry in Acetonitrile–Water Films Induced by Slow (<15 eV) Electrons: Application to the Earth and Space Chemistry. ACS Earth and Space Chemistry, 2022, 6 (4), pp.1126-1132. ⟨10.1021/acsearthspacechem.2c00024⟩. ⟨hal-03620854⟩
  • George Dedes, Jannis Dickmann, Valentina Giacometti, Simon Rit, Nils Krah, et al.. The role of Monte Carlo simulation in understanding the performance of proton computed tomography. Zeitschrift fur Medizinische Physik, 2022, 32, pp.23-38. ⟨10.1016/j.zemedi.2020.06.006⟩. ⟨hal-02920133⟩

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