Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for B^0_s -> mu^+mu^- and B^0 -> mu^+mu^- decays in pp collisions at 7 TeV. Physical Review Letters, 2011, 107, pp.191802. ⟨10.1103/PhysRevLett.107.191802⟩. ⟨in2p3-00624289⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for Resonances in the Dijet Mass Spectrum from 7 TeV pp Collisions at CMS. Physics Letters B, 2011, 704, pp.123-142. ⟨10.1016/j.physletb.2011.09.015⟩. ⟨in2p3-00611258⟩
  • M. Martini, M. Ericson, G. Chanfray. Neutrino quasielastic interaction and nuclear dynamics. Physical Review C, 2011, 84, pp.055502. ⟨10.1103/PhysRevC.84.055502⟩. ⟨in2p3-00628686⟩
  • G. Chanfray, M. Ericson. Scalar fields in nuclear matter: the roles of spontaneous chiral symmetry breaking and nucleon structure. Physical Review C, 2011, 83, pp.015204. ⟨10.1103/PhysRevC.83.015204⟩. ⟨in2p3-00537322⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Search for neutral Higgs bosons in the multi-b-jet topology in 5.2fb-1 of ppbar collisions at sqrt(s)=1.96 TeV. Physics Letters B, 2011, 698, pp.97-104. ⟨10.1016/j.physletb.2011.02.062⟩. ⟨in2p3-00534565⟩
  • L. Grevillot, T. Frisson, D. Maneval, N. Zahra, J.-N. Badel, et al.. Simulation of a 6 MV Elekta Precise Linac photon beam using GATE/GEANT4. Physics in Medicine and Biology, 2011, 56 (4), pp.903-918. ⟨10.1088/0031-9155/56/4/002⟩. ⟨in2p3-00842390⟩
  • X. Lojacono, M.-H. Richard, C. Ray, D. Dauvergne, E. Testa, et al.. Image reconstruction for Compton camera applied to 3D prompt imaging during ion beam therapy. IEEE Nuclear Science Symposium and Medical Imaging Conference, 2011, Valencia, Spain. pp.3518 - 3521, ⟨10.1109/NSSMIC.2011.6152647⟩. ⟨hal-01920979⟩
  • S. Ferrandon, P. Saultier, P. Battiston-Montagne, M. Beuve, C. Rodriguez-Lafrasse, et al.. Telomeric and radioresistance status of glioblastomas: a predictive marker for referrals to hadrontherapy. Bulletin du Cancer, 2011, 98, pp.S102. ⟨in2p3-00842383⟩
  • S. Chiacchiera, T. Lepers, D. Davesne, Michael Urban. Role of fourth-order phase-space moments in collective modes of trapped Fermi gases. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 2011, 84, pp.043634. ⟨10.1103/PhysRevA.84.043634⟩. ⟨in2p3-00649958⟩
  • M. Gherrab, N. Millard-Pinard, S. Gavarini, V. Garnier, Yves Jorand, et al.. Microstructure evolution of titanium carbide monoliths sintered by SPS and HP under extreme conditions of temperature and irradiation. EUROMAT 2011, 2011, Montpellier, France. ⟨in2p3-01018360⟩

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