Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • K. Aamodt, Sang Un Ahn, N. Arbor, Laurent Aphecetche, Y.W. Baek, et al.. Higher harmonic anisotropic flow measurements of charged particles in Pb-Pb collisions at 2.76 TeV. Physical Review Letters, 2011, 107, pp.032301. ⟨10.1103/PhysRevLett.107.032301⟩. ⟨in2p3-00595710⟩
  • K. Aamodt, A. Abrahantes Quintana, D. Adamova, A.M. Adare, M.M. Aggarwal, et al.. Production of pions, kaons and protons in pp collisions at sqrt(s)= 900 GeV with ALICE at the LHC. European Physical Journal C: Particles and Fields, 2011, 71, pp.1655. ⟨10.1140/epjc/s10052-011-1655-9⟩. ⟨in2p3-00558763⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. High mass exclusive diffractive dijet production in \mathbf{p\bar{p}} collisions at \mathbf{\sqrt{s}} = 1.96 TeV. Physics Letters B, 2011, 705, pp.193-199. ⟨10.1016/j.physletb.2011.10.013⟩. ⟨in2p3-00518487⟩
  • C. Adloff, K. Francis, J. Repond, J. Smith, D. Trojand, et al.. Effects of high-energy particle showers on the embedded front-end electronics of an electromagnetic calorimeter for a future lepton collider. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2011, 654, pp.97-109. ⟨10.1016/j.nima.2011.06.056⟩. ⟨in2p3-00567085⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Measurement of the Underlying Event Activity at the LHC with sqrt(s)= 7 TeV and Comparison with sqrt(s) = 0.9 TeV. Journal of High Energy Physics, 2011, 9, pp.109. ⟨10.1007/JHEP09(2011)109⟩. ⟨in2p3-00605964⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Measurement of the lepton charge asymmetry in inclusive W production in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2011, 04, pp.050. ⟨10.1007/JHEP04(2011)050⟩. ⟨in2p3-00577978⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Charged particle transverse momentum spectra in pp collisions at sqrt(s) = 0.9 and 7 TeV. Journal of High Energy Physics, 2011, 8, pp.086. ⟨10.1007/JHEP08(2011)086⟩. ⟨in2p3-00587101⟩
  • V. Khachatryan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Upsilon production cross section in pp collisions at sqrt(s)=7 TeV. Physical Review D, 2011, 83, pp.112004. ⟨10.1103/PhysRevD.83.112004⟩. ⟨in2p3-00554890⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Measurement of the top quark pair production cross section in the lepton+jets channel in proton-antiproton collisions at \sqrt{s}=1.96 TeV. Physical Review D, 2011, 84, pp.012008. ⟨10.1103/PhysRevD.84.012008⟩. ⟨in2p3-00551951⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for Same-Sign Top-Quark Pair Production at sqrt(s) = 7 TeV and Limits on Flavour Changing Neutral Currents in the Top Sector. Journal of High Energy Physics, 2011, 8, pp.005. ⟨10.1007/JHEP08(2011)005⟩. ⟨in2p3-00641347⟩

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