Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • V. Khachatryan, A.M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, et al.. Search for Pair Production of First-Generation Scalar Leptoquarks in pp Collisions at sqrt(s) = 7 TeV. Physical Review Letters, 2011, 106, pp.201802. ⟨10.1103/PhysRevLett.106.201802⟩. ⟨in2p3-00553528⟩
  • K. Aamodt, Sang Un Ahn, N. Arbor, Laurent Aphecetche, Y.W. Baek, et al.. Higher harmonic anisotropic flow measurements of charged particles in Pb-Pb collisions at 2.76 TeV. Physical Review Letters, 2011, 107, pp.032301. ⟨10.1103/PhysRevLett.107.032301⟩. ⟨in2p3-00595710⟩
  • K. Aamodt, A. Abrahantes Quintana, D. Adamova, A.M. Adare, M.M. Aggarwal, et al.. Production of pions, kaons and protons in pp collisions at sqrt(s)= 900 GeV with ALICE at the LHC. European Physical Journal C: Particles and Fields, 2011, 71, pp.1655. ⟨10.1140/epjc/s10052-011-1655-9⟩. ⟨in2p3-00558763⟩
  • J M Létang, M. Chevallier, D. Dauvergne, N. Freud, G. Montarou, et al.. Real-time monitoring of ion ranges. Workshop on Hadron Beam Therapy of Cancer, Erice, 2011, Unknown, Unknown Region. ⟨hal-01920976⟩
  • A. Pastore, S. Baroni, C. Losa. On the superfluid properties of the inner crust of neutron stars. Physical Review C, 2011, 84, pp.065807. ⟨10.1103/PhysRevC.84.065807⟩. ⟨in2p3-00666193⟩
  • Y. Zoccarato, W. Tromeur, S. Aguilar, R. Alfaro, E. Almaraz Avina, et al.. Front end electronics and first results of the ALICE V0 detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2011, 126-127, pp.90-96. ⟨10.1016/j.nima.2010.10.025⟩. ⟨in2p3-01057019⟩
  • Sacha Davidson, Veronica Sanz. Non-Standard Neutrino Interactions at Colliders. Physical Review D, 2011, 84, pp.113011. ⟨10.1103/PhysRevD.84.113011⟩. ⟨in2p3-00638757⟩
  • M.-G. Porquet, A. Astier, D. Verney, Ts. Venkova, I. Deloncle, et al.. Medium-spin states in neutron-rich 83As and 81As. Physical Review C, 2011, 84, pp.054305. ⟨10.1103/PhysRevC.84.054305⟩. ⟨in2p3-00644045⟩
  • A. Ouadi, E. Jobin, O. Klimchuk, C. Gaillard, I. Billard. CMPO functionalized task specific ionic liquid for actinide and lanthanide extraction. Fray International Symposium - Molten salts and Ionic Liquids, 2011, Cancun, Mexico. ⟨in2p3-01018394⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for Physics Beyond the Standard Model Using Multilepton Signatures in pp Collisions at sqrt(s)=7 TeV. Physics Letters B, 2011, 704, pp.411-433. ⟨10.1016/j.physletb.2011.09.047⟩. ⟨in2p3-00598586⟩

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