Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • Thibaut Capron, A. Perrat-Mabilon, C. Peaucelle, Tristan Meunier, David Carpentier, et al.. Remanence effects in the electrical resistivity of spin glasses. EPL - Europhysics Letters, 2011, 93 (2), pp.27001. ⟨10.1209/0295-5075/93/27001⟩. ⟨hal-00537114⟩
  • Y. Pipon, N. Toulhoat, N. Bérerd, N. Moncoffre, D. Roudil, et al.. Helium behavior in natural uranium oxides studied by nuclear reaction. Migration 2011 - International Conference on the Chemistry and Migration Behaviour of Actinides and Fission Products in the Geosphere, 2011, Beijing, China. ⟨in2p3-01018386⟩
  • A. Gadea, E. Farnea, J.J. Valiente-Dobon, B. Million, D. Mengoni, et al.. Conceptual design and infrastructure for the installation of the first AGATA sub-array at LNL. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2011, 654, pp.88-96. ⟨10.1016/j.nima.2011.06.004⟩. ⟨in2p3-00628776⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Measurement of the t t-bar Production Cross Section in pp Collisions at 7 TeV in Lepton + Jets Events Using b-quark Jet Identification. Physical Review D, 2011, 84, pp.092004. ⟨10.1103/PhysRevD.84.092004⟩. ⟨in2p3-00624257⟩
  • V. Abazov, F. Badaud, Pascal Gay, Ph. Gris, G. Sajot, et al.. Search for neutral minimal supersymmetric standard model Higgs Bosons decaying to tau pairs produced in association with b quarks in ppbar collisions at sqrt(s)=1.96 TeV. Physical Review Letters, 2011, 107, pp.121801. ⟨10.1103/PhysRevLett.107.121801⟩. ⟨in2p3-00603661⟩
  • Andrey Popov, Elena Kondratieva, Jean-Pierre Gilson, Laurence Mariey, Arnaud Travert, et al.. IR study of the interaction of phenol with oxides and sulfided CoMo catalysts for bio-fuel hydrodeoxygenation. Catalysis Today, 2011, 172 (1), pp.132--135. ⟨10.1016/j.cattod.2011.02.010⟩. ⟨hal-01840384⟩
  • Francisco Chinesta, Adrien Leygue, Elías Cueto, Roland Keunings. Efficient Solution of Highly Multidimensional Models By Using the Proper Generalized Decomposition: Towards a Change of Paradigm in Computational Mechanics. 4th Workshop on High-Dimensional Approximation, 2011, Bonn, Germany. ⟨hal-01008125⟩
  • G. Gutierrez, N. Toulhoat, N. Moncoffre, Y. Pipon, Alexandre Maitre, et al.. Thermal behaviour of xenon in zirconium carbide at high temperature: Role of residual zirconia and free carbon. Journal of Nuclear Materials, 2011, 416, pp.94-98. ⟨10.1016/j.jnucmat.2010.11.103⟩. ⟨in2p3-00650290⟩
  • R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, W. M. Chen, et al.. A comparative measurement of \phi\rightarrow K^+K^- and \phi\rightarrow \mu^+\mu^- in In-In collisions at the CERN SPS. Physics Letters B, 2011, 699, pp.325-329. ⟨10.1016/j.physletb.2011.04.028⟩. ⟨in2p3-00589263⟩
  • V. Khachatryan, A.M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, et al.. Search for Pair Production of First-Generation Scalar Leptoquarks in pp Collisions at sqrt(s) = 7 TeV. Physical Review Letters, 2011, 106, pp.201802. ⟨10.1103/PhysRevLett.106.201802⟩. ⟨in2p3-00553528⟩

Powered by HAL logo