Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Vardan Khachatryan, Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, et al.. Exclusive and semi-exclusive pi+pi- production in proton-proton collisions at sqrt(s) = 7 TeV. 2019. ⟨hal-02411002⟩
    • B. Abi, R. Acciarri, M.A. Acero, M. Adamowski, C. Adams, et al.. The Single-Phase ProtoDUNE Technical Design Report. 2019. ⟨hal-02410822⟩
    • Sylvain Pasquet, Marina Rosas-Carbajal, Jacques Marteau, Jean-Christophe Ianigro, Konstantinos Chalikakis, et al.. Combined Muon, Seismic and Electrical Resistivity Measurements to Characterize a Karstic Unsaturated Zone (LSBB, France). AGU Fall Meeting 2019, Dec 2019, San Francisco, United States. ⟨hal-02364484⟩
    • Matias Tramontini, Marina Rosas-Carbajal, Christophe Nussbaum, Dominique Gibert, Jacques Marteau. Middle-atmosphere Dynamics Studied with a Portable Muon Detector at the Mont Terri Underground Rock Laboratory, Switzerland. American Geophysical Union Fall Meeting 2019, Dec 2019, San Francisco, United States. , pp.NS43B-0834, 2019. ⟨insu-02402695⟩
    • Jacques Marteau, Marina Rosas-Carbajal, Matias Tramontini, Fabio Zyserman, Jean de Bremond d'Ars, et al.. Muographic long-term monitoring of the Soufrière of Guadeloupe with a system of coupled muon detection systems. American Geophysical Union Fall Meeting 2019, Dec 2019, San Francisco, United States. , pp.NS43B-0832, 2019. ⟨insu-02402582⟩
    • M. Rosas-Carbajal, M. Tramontini, C. Nussbaum, Dominique Gibert, J. Marteau. Middle-atmosphere Dynamics Studied with a Portable Muon Detector at the Mont Terri Underground Rock Laboratory, Switzerland.. American Geophysical Union, Dec 2019, San francisco, United States. pp.555-577. ⟨hal-03551044⟩
    • Michele Gallinaro, Kenneth Long, Jurgen Reuter, Richard Ruiz, Dinos Bachas, et al.. Beyond the Standard Model in Vector Boson Scattering Signatures. International Workshop on BSM models in Vector Boson Scattering processes, Dec 2019, Lisbon, Portugal. ⟨hal-03143733⟩
    • O. Allegrini, J. P. Cachemiche, C. Caplan, B. Carlus, X. Chen, et al.. Test and characterization of the CLaRyS camera's absorber with its final acquisition chain. Young Investigator's Workshop on Photon Detection in Medicine and Medical Physics - 2019, Dec 2019, Siegen, Germany. . ⟨hal-02408478⟩
    • Victor Mukhamedovich Abazov, Braden Keim Abbott, Bannanje Sripath Acharya, Mark Raymond Adams, Todd Adams, et al.. Inclusive production of the P_c resonances in p \overline p collisions. 2019. ⟨hal-02382006⟩
    • B. Liu, I. Laktineh, Q. Shen, G. Garillot, J. Guo, et al.. Particle identification using Boosted Decision Trees in the semi-digital hadronic calorimeter. 3rd Conference on Calorimetry for the High Energy Frontier, Nov 2019, Fukuoka, Japan. pp.C05022, ⟨10.1088/1748-0221/15/05/c05022⟩. ⟨hal-02981308⟩

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