Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • K. Abe, N. Abgrall, H. Aihara, Y. Ajima, J. B. Albert, et al.. The T2K Experiment. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2011, 659, pp.106-135. ⟨10.1016/j.nima.2011.06.067⟩. ⟨in2p3-00609764⟩
  • Françoise Masson, Francisco Chinesta, Adrien Leygue, Elías Cueto, Laurent Dala, et al.. PGD Based Thermal Control of Aircraft Wings. ECCOMAS Thematic Workshop on Reduced Basis, POD and PGD Model Reduction Techniques, 2011, Paris, France. ⟨hal-01008659⟩
  • Françoise Masson, Adrien Leygue, Francisco Chinesta, Elías Cueto. Dynamic Data-Driven Inverse Identification in Dynamical Systems. 11th International Conference on Computational Plasticity (COMPLAS), 2011, Barcelona, Spain. ⟨hal-01008085⟩
  • I. Declais. Measurement of the neutrino velocity with the OPERA detector in the CNGS beam. VirginiaTech Sterile Neutrinos at the crossroad, 2011, Blacksburg, United States. ⟨in2p3-01019751⟩
  • A. Knebe, N.I. Libeskind, T. Doumler, G. Yepes, S. Gottlober, et al.. Renegade subhaloes in the Local Group. Monthly Notices of the Royal Astronomical Society, 2011, 417, pp.L56-L60. ⟨10.1111/j.1365-2966.2011.18094.x⟩. ⟨in2p3-00684095⟩
  • J. Krimmer, P. Aguar Bartolomé, J. Ahrens, S. Altieri, H.J. Arends, et al.. A polarized 3He target for the photon beam at MAMI. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2011, 648, pp.35-40. ⟨10.1016/j.nima.2011.05.051⟩. ⟨in2p3-00842355⟩
  • D. Dauvergne, M. Chevallier, N. Freud, J.-M. Létang, Gerard Montarou, et al.. Novel imaging systems for online control of ion therapy. Bulletin du Cancer, 2011, 98, pp.S101-S101. ⟨in2p3-00702752⟩
  • J. Vijande, A. Valcarce, J.-M. Richard. Stability of hexaquarks in the string limit of confinement. Physical Review D, 2011, 85, pp.014019. ⟨10.1103/PhysRevD.85.014019⟩. ⟨in2p3-00722282⟩
  • A. Arbey, F. Mahmoudi. SuperIso Relic v3.0: A program for calculating relic density and flavour physics observables: Extension to NMSSM. Computer Physics Communications, 2011, 182, pp.1582-1583. ⟨10.1016/j.cpc.2011.03.019⟩. ⟨in2p3-00683890⟩
  • Sacha Davidson, P. Verdier. Leptoquarks decaying to a top quark and a charged lepton at hadron colliders. Physical Review D, 2011, 83, pp.115016. ⟨10.1103/PhysRevD.83.115016⟩. ⟨in2p3-00568510⟩

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