Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • R. Tieulent. Heavy flavour and quarkonium at forward and central rapidity in p-p collisions with ALICE at LHC. Cracow Epiphany Conference on the First Year of the LHC, Jan 2011, Cracovie, Poland. pp.1655-1662, ⟨10.5506/APhysPolB.42.1655⟩. ⟨in2p3-00610805⟩
  • T. Rollin, G. Aldering, C. Aragon, P. Antilogus, C. Baltay, et al.. Analysis of the Type Ia Supernova SNF20080514-002. 217th Meeting of the American Astronomical Society with the Historical Astronomy, Jan 2011, Seattle, WA, United States. pp.30801. ⟨in2p3-00611463⟩
  • H. Fakhouri, G. Aldering, C. Aragon, E. Hsiao, S. Loken, et al.. Twin Supernova Studies with SNe Ia from SNfactory. 217th Meeting of the American Astronomical Society with hte Historical Astronomy, Jan 2011, Seattle, WA, United States. pp.337-13. ⟨in2p3-00611459⟩
  • V. Khachatryan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Inclusive b-hadron production cross section with muons in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2011, 03, pp.090. ⟨10.1007/JHEP03(2011)090⟩. ⟨in2p3-00557490⟩
  • N. Agafonova, Alexander Aleksandrov, O. Altinok, A. Anokhina, S. Aoki, et al.. Study of neutrino interactions with the electronic detectors of the OPERA experiment. New Journal of Physics, 2011, 13, pp.053051. ⟨10.1088/1367-2630/13/5/053051⟩. ⟨in2p3-00564791⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Forward-backward asymmetry in top quark-antiquark production. Physical Review D, 2011, 84, pp.112005. ⟨10.1103/PhysRevD.84.112005⟩. ⟨in2p3-00611263⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Measurement of the production fraction times branching fraction f(b --> \Lambda_b)B(\Lambda_b --> J/\psi \Lambda). Physical Review D, 2011, 84, pp.031102(R). ⟨10.1103/PhysRevD.84.031102⟩. ⟨in2p3-00590761⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for a Vector-like Quark with Charge 2/3 in t + Z Events from pp Collisions at sqrt(s) = 7 TeV. Physical Review Letters, 2011, 107, pp.271802. ⟨10.1103/PhysRevLett.107.271802⟩. ⟨in2p3-00626353⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for a W' boson decaying to a muon and a neutrino in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2011, 701, pp.160-179. ⟨10.1016/j.physletb.2011.05.048⟩. ⟨in2p3-00572670⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Measurement of color flow in t-tbar events from p-pbar collisions at sqrt(s)=1.96 TeV. Physical Review D, 2011, 83, pp.092002. ⟨10.1103/PhysRevD.83.092002⟩. ⟨in2p3-00551950⟩

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