Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • I. Laktineh. Construction of a Semi-Digital Hadronic Calorimeter Protoype. 4th Workshop of France China Particle Physics Laboratory (FCPPL), Apr 2011, Jinan, China. ⟨in2p3-01011113⟩
  • R. Chehab. Positron beams for linear colliders: generation and capture. 4th Workshop of France China Particle Physics Laboratory (FCPPL), Apr 2011, Jinan, China. ⟨in2p3-01011119⟩
  • S. Gascon-Shotkin. Photon studies for LHC startup physics. 4th Workshop of France China Particle Physics Laboratory (FCPPL), Apr 2011, Jinan, China. ⟨in2p3-01011111⟩
  • G. Boudoul. Simulation of the Tracker implementation in the electronic trigger at the super-LHC. 4th Workshop of France China Particle Physics Laboratory (FCPPL), Apr 2011, Jinan, China. ⟨in2p3-00967155⟩
  • Dominique Gibert, N. Lesparre, Jacques Marteau, Florence Nicollin, Bruno Kergosien, et al.. Muon tomography and Volcanic Risks in the Lesser Antilles: the Example of the Soufrière of Guadeloupe. EGU General Assembly 2011, European Geoscience Union, Apr 2011, Vienne, Austria. pp.EGU2011-3983. ⟨insu-01116984⟩
  • M. Gherrab, N. Millard-Pinard, S. Gavarini, V. Garnier. Synthèse et caractĂ©risation de carbure de titane nanostructurĂ© pour utilisation en conditions extrĂŞmes, Application en tant que matĂ©riau d'enrobage du combustible dans les rĂ©acteurs nuclĂ©aires de GĂ©nĂ©ration IV. JournĂ©e Macodev, Apr 2011, Lyon, France. ⟨in2p3-01018549⟩
  • M. Kibler. Participation Ă  l'animation d'une table ronde. 7th International Microconference on Analytic and Algebraic Methods in Physics, Mar 2011, Prague, Czech Republic. ⟨in2p3-00763276⟩
  • HervĂ© Chanal, D. Contardo, Y. Zoccarato. A Front End chip development for triggering with Silicon Strip Pt-modules. Third Common ATLAS CMS Electronics Workshop for LHC upgrades (ACES2011), Mar 2011, CERN, Switzerland. ⟨in2p3-00581085⟩
  • L. Li, W. Chen, W. Dong, X. Chen. Critical behavior of two-dimensional magnetic lattice gas model. The European Physical Journal B: Condensed Matter and Complex Systems, 2011, 80 (2), pp.189 - 193. ⟨10.1140/epjb/e2011-10948-9⟩. ⟨hal-01889621⟩
  • TimothĂ©e Brugière. Oscillations des neutrinos sur et hors faisceau : Ă©tude des performances du système d’acquisition d’OPERA. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2011. Français. ⟨NNT : 2011LYO10035⟩. ⟨tel-01825526⟩

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