Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
393 documents

  • R.M. Clark, R. Wadsworth, E.S. Paul, C.W. Beausang, I. Ali, et al.. Collective oblate dipole rotational bands in ^{198}pb. Nuclear Physics A, 1993, 562, pp.121-156. ⟨in2p3-00007598⟩
  • Nathalie Millard-Pinard, Nathalie Moncoffre, Henri Jaffrezic, Gilbert Marest. Modelization of nitrogen diffusion induced by the formation of a surface carbonitride layer. Japanese Journal of Applied Physics, 1993, 74 (10), pp.6032-6038. ⟨10.1063/1.355218⟩. ⟨in2p3-00013034⟩
  • P.J. Dagnall, C.W. Beausang, P. Fallon, P.D. Forsyth, E.S. Paul, et al.. Coexistence of collective oblate and superdeformed prolate shapes in ^{196}Pb. Journal of Physics G: Nuclear and Particle Physics, 1993, 19, pp.465-470. ⟨in2p3-00007597⟩
  • R.M. Clark, R. Wadsworth, E.S. Paul, C.W. Beausang, I. Ali, et al.. Short note collective dipole rotational bands in ^{197}Pb. Zeitschrift für Physik. A, Atoms and Nuclei, 1992, 342, pp.371-372. ⟨in2p3-00007613⟩
  • R.M. Clark, R. Wadsworth, E.S. Paul, C.W. Beausang, I. Ali, et al.. First observation of a collective dipole rotational band in the a environ 200 mass region. Physics Letters B, 1992, 275, pp.247-251. ⟨in2p3-00007610⟩
  • P. Decowski, E. Gierlik, P.F. Box, K.A. Griffioen, R.J. Meijer, et al.. Mutual inelastic excitation in the ^{28}Si + ^{28}Si reaction at 19.7 and 30 MeV/nucleon. Physical Review C, 1992, 46, pp.667-676. ⟨10.1103/PhysRevC.46.667⟩. ⟨in2p3-00013084⟩
  • P. Decowski, E. Gierlik, P.F. Box, K.A. Griffioen, R. Kamermans, et al.. Entrance channel effects in the ^{28}Si + ^{28}Si reaction. International Winter Meeting on Nuclear Physics.29, Jan 1991, Bormio, Italy. pp.585-602. ⟨in2p3-00004248⟩
  • U. Milkau, E. Berdermann, B. Berthier, P. Bouissou, C. Cerruti, et al.. Intermediate mass fragments from ^{40}Ar+^{197}Au:transition from the incomplete fusion to the participant spectator regime. Physical Review C, 1991, 44, pp.R1242-R1245. ⟨in2p3-00014640⟩
  • P.F. Box, T.M.V. Bootsma, C. Twenhoefel, P. Decowski, G.J. Van Nieuwenhuizen, et al.. Complex fragment emission in ^{28}Si + ^{nat}Si. Spring Meeting on Nuclear Physics Sections of the DPG, Mar 1990, Strasbourg, France. pp.1404-(A2.2). ⟨in2p3-00007227⟩
  • P. Decowski, F. Altena, P.F. Box, E. Gierlik, K.A. Griffioen, et al.. Saturation effects in the fusion of ^{28}Si nuclei at bombarding energies between 20 and 35 MeV/nucleon. International Winter Meeting On Nuclear Physics 28, Jan 1990, Bormio, Italy. pp.368-380. ⟨in2p3-00013364⟩

Powered by HAL logo