Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for a light charged Higgs boson in the H^\pm \to cs channel in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.D, 2020, 102 (7), pp.072001. ⟨10.1103/PhysRevD.102.072001⟩. ⟨hal-02739653⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Evidence for top quark production in nucleus-nucleus collisions. Phys.Rev.Lett., 2020, 125 (22), pp.222001. ⟨10.1103/PhysRevLett.125.222001⟩. ⟨hal-02892964⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Constraining the Chiral Magnetic Effect with charge-dependent azimuthal correlations in Pb-Pb collisions at \sqrt{s_{\mathrm{NN}}} = 2.76 and 5.02 TeV. Journal of High Energy Physics, 2020, 09, pp.160. ⟨10.1007/JHEP09(2020)160⟩. ⟨hal-02870818⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Performance of the reconstruction and identification of high-momentum muons in proton-proton collisions at \sqrt{s} = 13 TeV. JINST, 2020, 15 (02), pp.P02027. ⟨10.1088/1748-0221/15/02/P02027⟩. ⟨hal-02431472⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for heavy Higgs bosons decaying to a top quark pair in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2020, 04, pp.171. ⟨10.1007/JHEP04(2020)171⟩. ⟨hal-02290824⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Identification of heavy, energetic, hadronically decaying particles using machine-learning techniques. JINST, 2020, 15 (06), pp.P06005. ⟨10.1088/1748-0221/15/06/P06005⟩. ⟨hal-02564603⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for direct top squark pair production in events with one lepton, jets, and missing transverse momentum at 13 TeV with the CMS experiment. JHEP, 2020, 05, pp.032. ⟨10.1007/JHEP05(2020)032⟩. ⟨hal-02431418⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of B_\mathrm{c}(2S)^+ and B_\mathrm{c}^*(2S)^+ cross section ratios in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.D, 2020, 102 (9), pp.092007. ⟨10.1103/PhysRevD.102.092007⟩. ⟨hal-02934074⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for decays of the 125 GeV Higgs boson into a Z boson and a \rho or \phi meson. JHEP, 2020, 11, pp.039. ⟨10.1007/JHEP11(2020)039⟩. ⟨hal-02911926⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for an excited lepton that decays via a contact interaction to a lepton and two jets in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2020, 05, pp.052. ⟨10.1007/JHEP05(2020)052⟩. ⟨hal-02467300⟩

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