Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Stahl, P del Amo Sanchez, D. Duchesneau, H. Pessard, F. Cadoux, et al.. Expression of Interest for a very long baseline neutrino oscillation experiment (LBNO). [Research Report] CERN-SPSC-2012-021, SPSC-EOI-007, CERN. 2012. ⟨in2p3-01019272⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV. Physical Review Letters, 2012, 109, pp.022301. ⟨10.1103/PhysRevLett.109.022301⟩. ⟨in2p3-00686353⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for high mass resonances decaying into tau-lepton pairs in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2012, 716, pp.82-102. ⟨10.1016/j.physletb.2012.07.062⟩. ⟨in2p3-00706603⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2012, 714, pp.136-157. ⟨10.1016/j.physletb.2012.05.063⟩. ⟨in2p3-00694341⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Measurement of the charge asymmetry in top-quark pair production in proton-proton collisions at sqrt(s) = 7 TeV. Physics Letters B, 2012, 709, pp.28-49. ⟨10.1016/j.physletb.2012.01.078⟩. ⟨in2p3-00654503⟩
  • V. M. Abazov, B. Abbott, B. S. Acharya, M. Adams, T. Adams, et al.. Search for pair production of the scalar top quark in muon+tau final states. Physics Letters B, 2012, 710, pp.578-586. ⟨10.1016/j.physletb.2012.03.028⟩. ⟨in2p3-00672400⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for heavy, top-like quark pair production in the dilepton final state in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2012, 716, pp.103-121. ⟨10.1016/j.physletb.2012.07.059⟩. ⟨in2p3-00682855⟩
  • Z. Abou-Haidar, C. Agodi, M.A.G. Alvarez, M. Anelli, T. Aumann, et al.. Performance of upstream interaction region detectors for the FIRST experiment at GSI. Journal of Instrumentation, 2012, 7, pp.P02006. ⟨10.1088/1748-0221/7/02/P02006⟩. ⟨in2p3-00676714⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for anomalous t t-bar production in the highly-boosted all-hadronic final state. Journal of High Energy Physics, 2012, 9, pp.29. ⟨10.1007/JHEP09(2012)029⟩. ⟨in2p3-00687026⟩
  • B. Abelev, N. Arbor, G. Conesa Balbastre, J. Faivre, C. Furget, et al.. Production of K*(892)^0 and phi(1020) in pp collisions at sqrt(s)=7 TeV. European Physical Journal C: Particles and Fields, 2012, 72, pp.2183. ⟨10.1140/epjc/s10052-012-2183-y⟩. ⟨in2p3-00727668⟩

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