Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2012, 03, pp.40. ⟨10.1007/JHEP03(2012)040⟩. ⟨in2p3-00672495⟩
- V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Measurement of the Lambda_b^0 lifetime in the exclusive decay Lambda_b^0 -> J/psi Lambda^0 in ppbar collisions at sqrt(s)=1.96 TeV. Physical Review D, 2012, 85, pp.112003. ⟨10.1103/PhysRevD.85.112003⟩. ⟨in2p3-00687028⟩
- M. Gouzevitch. CMS New fermions and gauge interactions. Implications of LHC results for TeV-scale physics, 2012, Genève, Switzerland. ⟨in2p3-00967969⟩
- N. Lesparre, D. Gibert, J. Marteau. Bayesian dual inversion of experimental telescope acceptance and integrated flux for geophysical muon tomography. Geophysical Journal International, 2012, 188, pp.490-497. ⟨10.1111/j.1365-246X.2011.05268.x⟩. ⟨in2p3-00666938⟩
- V.M. Abazov, F. Badaud, U. Bassler, G. Bernardi, M. Besancon, et al.. An improved determination of the width of the top quark. Physical Review D, 2012, 85, pp.091104(R). ⟨10.1103/PhysRevD.85.091104⟩. ⟨in2p3-00661675⟩
- V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Search for doubly charged Higgs boson pair production in ppbar collisions at sqrt{s} = 1.96 TeV. Physical Review Letters, 2012, 108, pp.021801. ⟨10.1103/PhysRevLett.108.021801⟩. ⟨in2p3-00602328⟩
- C. Smith. Proton stability from a fourth family. Physical Review D, 2012, 85, pp.036005. ⟨10.1103/PhysRevD.85.036005⟩. ⟨in2p3-00694507⟩
- T. Aaltonen, H. Li, G. Sajot, J. Stark, J.-F. Grivaz, et al.. Search for Neutral Higgs Bosons in Events with Multiple Bottom Quarks at the Tevatron. Physical Review D, 2012, 86, pp.091101(R). ⟨10.1103/PhysRevD.86.091101⟩. ⟨in2p3-00718072⟩
- F. Gagnon-Moisan, E. Galichet, M.-F. Rivet, B. Borderie, M. Colonna, et al.. New isospin effects in central heavy-ion collisions at Fermi energies. Physical Review C, 2012, 86, pp.044617. ⟨10.1103/PhysRevC.86.044617⟩. ⟨in2p3-00736381⟩
- Elisabeth Massot, Jérôme Margueron, G. Chanfray. On the maximum mass of hyperonic neutron stars. EPL - Europhysics Letters, 2012, 97, pp.39002. ⟨10.1209/0295-5075/97/39002⟩. ⟨in2p3-00659024⟩
Powered by HAL 