Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • R. Scalzo, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. A Search for New Candidate Super-Chandrasekhar-Mass Type Ia Supernovae in the Nearby Supernova Factory Dataset. The Astrophysical Journal, 2012, 757, ⟨10.1088/0004-637X/757/1/12⟩. ⟨in2p3-00717457⟩
  • A. Arbey, M. Battaglia, F. Mahmoudi. Light Neutralino Dark Matter in the pMSSM: Implications of LEP, LHC and Dark Matter Searches on SUSY Particle Spectra. European Physical Journal C: Particles and Fields, 2012, 72, pp.1-13. ⟨10.1140/epjc/s10052-012-2169-9Authors⟩. ⟨in2p3-00722315⟩
  • B. Censier, Alain Benoit, G. Bres, F. Charlieu, J. Gascon, et al.. EDELWEISS Read-out Electronics and Future Prospects. Journal of Low Temperature Physics, 2012, 167, pp.645-651. ⟨10.1007/s10909-012-0568-9⟩. ⟨in2p3-00702825⟩
  • P. Bourgeois, B. Cordier, A. Dominjon, H. El Mamouni, O. Limousin, et al.. New Developments in Photodetection NDIP11. 6th International Conference on New Developments in Photodetection (NDIP 2011), Jul 2011, Lyon, France. 695, pp.1-444, 2012. ⟨in2p3-00744727⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Search for a Narrow ttbar Resonance in ppbar Collisions at sqrt{s}=1.96 TeV. Physical Review D, 2012, 85, pp.051101(R). ⟨10.1103/PhysRevD.85.051101⟩. ⟨in2p3-00639399⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s)=7 TeV. Journal of High Energy Physics, 2012, 11(2012), pp.067. ⟨10.1007/JHEP11(2012)067⟩. ⟨in2p3-00723843⟩
  • A. Pastore, D. Davesne, K. Bennaceur, J. Meyer, V. Hellemans. Fitting Skyrme functionals using linear response theory. 19th Workshop on Nuclear Physics 'Marie and Pierre Curie', 2012, Kazimierz Dolny, Poland. pp.014014, ⟨10.1088/0031-8949/2013/T154/014014⟩. ⟨in2p3-00747310⟩
  • F.D. Aaron, J.C. Bizot, V. Brisson, B. Delcourt, M. Jacquet, et al.. Determination of the Integrated Luminosity at HERA using Elastic QED Compton Events. European Physical Journal C: Particles and Fields, 2012, 72, pp.2163. ⟨10.1140/epjc/s10052-012-2163-2⟩. ⟨in2p3-00716960⟩
  • P. Veselý, J. Toivanen, B.G. Carlsson, J. Dobaczewski, N. Michel, et al.. Giant monopole resonances and nuclear incompressibilities studied for the zero-range and separable pairing interactions. Physical Review C, 2012, 86, pp.024303. ⟨10.1103/PhysRevC.86.024303⟩. ⟨in2p3-00730985⟩
  • Miguel Portela Sotelo, Elodie Desserée, Jean-Michel Moreau, Behzad Shariat, Michaël Beuve. 3D model-based multiple-object video tracking for treatment room supervision. IEEE Transactions on Biomedical Engineering, 2012, 59 (2), pp.562-570. ⟨10.1109/TBME.2011.2176940⟩. ⟨hal-00796457⟩

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