Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • C. Agodi, Z. Abou-Haidar, M.A.G. Alvarez, T. Aumann, F. Balestra, et al.. FIRST experiment: Fragmentation of Ions Relevant for Space and Therapy. 11th International Conference on Nucleus-Nucleus Collisions (NN2012), 2012, San Antonio, United States. pp.012061, ⟨10.1088/1742-6596/420/1/012061⟩. ⟨in2p3-00927023⟩
  • V.M. Abazov, U. Bassler, G. Bernardi, D. Brown, J. Brown, et al.. Observation of a narrow mass state decaying into Upsilon(1S) + gamma in ppbar collisions at sqrt(s) = 1.96 TeV. Physical Review D, 2012, 86, pp.031103(R). ⟨10.1103/PhysRevD.86.031103⟩. ⟨in2p3-00683165⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Inclusive and differential measurements of the t t-bar charge asymmetry in proton-proton collisions at 7 TeV. Physics Letters B, 2012, 717, pp.129-150. ⟨10.1016/j.physletb.2012.09.028⟩. ⟨in2p3-00713884⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Jet momentum dependence of jet quenching in PbPb collisions at sqrt(sNN)=2.76 TeV. Physics Letters B, 2012, 712, pp.176-197. ⟨10.1016/j.physletb.2012.04.058⟩. ⟨in2p3-00673208⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Measurement of the top-quark mass in t t-bar events with lepton+jets final states in pp collisions at sqrt(s)=7 TeV. Journal of High Energy Physics, 2012, 12, pp.105. ⟨10.1007/JHEP12(2012)105⟩. ⟨in2p3-00731238⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for B_s to mu^+ mu^- and B^0 to mu^+ mu^- decays. Journal of High Energy Physics, 2012, 4, pp.33. ⟨10.1007/JHEP04(2012)033⟩. ⟨in2p3-00680724⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for electroweak production of charginos and neutralinos using leptonic final states in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2012, 11, pp.147. ⟨10.1007/JHEP11(2012)147⟩. ⟨in2p3-00736969⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at sqrt(s) = 7 TeV. Physical Review Letters, 2012, 109, pp.171803. ⟨10.1103/PhysRevLett.109.171803⟩. ⟨in2p3-00716144⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV. Journal of Instrumentation, 2012, 7, pp.P10002. ⟨10.1088/1748-0221/7/10/P10002⟩. ⟨in2p3-00710068⟩
  • A. Stahl, P del Amo Sanchez, D. Duchesneau, H. Pessard, F. Cadoux, et al.. Expression of Interest for a very long baseline neutrino oscillation experiment (LBNO). [Research Report] CERN-SPSC-2012-021, SPSC-EOI-007, CERN. 2012. ⟨in2p3-01019272⟩

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