Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Cacciapaglia, A. Deandrea, L. Panizzi, N. Gaur, D. Harada, et al.. Heavy Vector-like Top Partners at the LHC and flavour constraints. Journal of High Energy Physics, 2012, 1203, pp.070. ⟨10.1007/JHEP03(2012)070⟩. ⟨in2p3-00618305⟩
  • A. Pastore, M. Martini, V. Buridon, D. Davesne, K. Bennaceur, et al.. Nuclear response for the Skyrme effective interaction with zero-range tensor terms. III. Neutron matter and neutrino propagation. Physical Review C, 2012, 86, pp.044308. ⟨10.1103/PhysRevC.86.044308⟩. ⟨in2p3-00718705⟩
  • M. Doser, L. Cabaret, D. Comparat, P. Nédélec. Exploring the WEP with a pulsed cold beam of antihydrogen. Classical and Quantum Gravity, 2012, 29, pp.184009. ⟨10.1088/0264-9381/29/18/184009⟩. ⟨in2p3-00742767⟩
  • A. Pastore. Superfluid properties of the inner crust of neutron stars. II. Wigner-Seitz cells at finite temperature. Physical Review C, 2012, 86, pp.065802. ⟨10.1103/PhysRevC.86.065802⟩. ⟨in2p3-00751220⟩
  • N. Lesparre, J. Marteau, Y. Déclais, Dominique Gibert, B. Carlus, et al.. Design and operation of a field telescope for cosmic ray geophysical tomography. Geoscientific Instrumentation, Methods and Data Systems, 2012, 1, pp.33-42. ⟨10.5194/gi-1-33-2012⟩. ⟨insu-00814367⟩
  • R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, W. M. Chen, et al.. J/psi production in proton-nucleus collisions at 158 and 400 GeV. Physics Letters B, 2012, 706, pp.263-267. ⟨10.1016/j.physletb.2011.11.042⟩. ⟨in2p3-00479844⟩
  • B. Abelev, Sang Un Ahn, Laurent Aphecetche, N. Arbor, Y.W. Baek, et al.. Measurement of charm production at central rapidity in proton-proton collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2012, 01(2012°, pp.128. ⟨10.1007/JHEP01(2012)128⟩. ⟨in2p3-00639079⟩
  • B. Abelev, R. Vernet, I. Belikov, B. Hippolyte, S. Jangal, et al.. Measurement of charm production at central rapidity in proton-proton collisions at sqrt(s) = 2.76 TeV. Journal of High Energy Physics, 2012, 7, pp.191. ⟨10.1007/JHEP07(2012)191⟩. ⟨in2p3-00705656⟩
  • E. Armengaud, C. Augier, Alain Benoit, L. Bergé, T. Bergmann, et al.. A search for low-mass WIMPs with EDELWEISS-II heat-and-ionization detectors. Physical Review D, 2012, 86, pp.051701. ⟨10.1103/PhysRevD.86.051701⟩. ⟨in2p3-00716140⟩
  • D. Chateau, F. Chaput, C. Lopes, M. Lindgren, C. Brannlund, et al.. Silica Hybrid Sol-Gel Materials with Unusually High Concentration of Pt-Organic Molecular Guests: Studies of Luminescence and Nonlinear Absorption of Light. Applied Materials & Interfaces, 2012, 4, pp.2369-2377. ⟨10.1021/am2015537⟩. ⟨in2p3-00709235⟩

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