The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

8786 documents

  • H.M. Courtois, R. B. Tully. Cosmic Flows surveys and CLUES simulations. Astronomical Notes / Astronomische Nachrichten, 2012, 333, pp.436. ⟨10.1002/asna.201211682⟩. ⟨in2p3-00699941⟩
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  • A. Pastore, D. Davesne, Y. Lallouet, M. Martini, K. Bennaceur, et al.. Nuclear response for the Skyrme effective interaction with zero-range tensor terms. II. Sum rules and instabilities. Physical Review C, 2012, 85, pp.054317. ⟨10.1103/PhysRevC.85.054317⟩. ⟨in2p3-00684899⟩
  • H. Samtleben, D. Tsimpis. Rigid supersymmetric theories in 4d Riemannian space. Journal of High Energy Physics, 2012, 1205, pp.132. ⟨10.1007/JHEP05(2012)132⟩. ⟨in2p3-00682815⟩
  • V. Buridon, C. Teyssier, H. Abdoul-Carime, B. Farizon, M. Farizon, et al.. The Correlation ion and neutral time of flight mass spectrometry. 19th International Mass Spectrometry Conference (IMSC 2012), 2012, Kyoto, Japan. ⟨in2p3-01010270⟩
  • A. Blondel, N. Moncoffre, N. Toulhoat, N. Bérerd. Effets de la radiolyse et de l'irradiation sur le comportement du chlore dans le graphite nucléaire. XIIIèmes Journées Nationales de Radiochimie et de Chimie Nucléaire, 2012, Nantes, France. ⟨in2p3-00981357⟩
  • G. Gawlik, G. Panczer, N. Moncoffre, J. Jagielski. Effect of Temperature on the Ion Beam Induced Luminescence of Oxide Powders Doped with Rare Earth Elements. 9th International Conference on Ion Implantation and Other Application of Ions and Electrons (ION), 2012, Kazimierz Dolny, Poland. pp.920-922, ⟨10.12693/APhysPolA.123.920⟩. ⟨in2p3-00840742⟩
  • A. Astier, M. -G. Porquet, Ts. Venkova, D. Verney, Ch. Theisen, et al.. High-spin structures of five N=82 isotones: 136Xe, 137Cs, 138Ba, 139La, and 140Ce. Physical Review C, 2012, 85, pp.064316. ⟨10.1103/PhysRevC.85.064316⟩. ⟨in2p3-00705628⟩
  • C. Guipponi, N. Millard-Pinard, N. Bérerd, Eric Serris, Michèle Pijolat, et al.. Modifications of oxidized Zircaloy-4 surface in contact with radiolysed wet air. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2012, 272, pp.222-226. ⟨10.1016/j.nimb.2011.01.070⟩. ⟨hal-00667455⟩
  • J.T. Parrent, D. A. Howell, B. Friesen, R. C. Thomas, R. A. Fesen, et al.. Analysis of the Early-Time Optical Spectra of SN 2011fe in M101. The Astrophysical Journal Letters, 2012, 752, pp.L26. ⟨10.1088/2041-8205/752/2/L26⟩. ⟨in2p3-00721794⟩