Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • C. Gaillard, I. Billard, A. Ouadi, S. Georg, V. Mazan, et al.. Speciation of lanthanides and actinides in ionic liquids by XAS. German-French research for nuclear safety: Chemistry of the f-elements, 2012, Strasbourg, France. ⟨in2p3-01018576⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for narrow resonances in dilepton mass spectra in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2012, 714, pp.158-179. ⟨10.1016/j.physletb.2012.06.051⟩. ⟨in2p3-00706614⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for heavy long-lived charged particles in pp collisions at sqrt(s)=7 TeV. Physics Letters B, 2012, 713, pp.408-433. ⟨10.1016/j.physletb.2012.06.023⟩. ⟨in2p3-00694347⟩
  • M. Gherrab, N. Millard-Pinard, S. Gavarini, V. Garnier, Sandrine Cardinal, et al.. Elaboration and characterization of titanium carbide monoliths sintered through SPS, HIP and HP. Materials Science and Technology 2012 Conference and Exhibition, 2012, Pittsburgh, United States. ⟨in2p3-01018428⟩
  • A. Azatov, O. Bondu, A. Falkowski, M. Felcini, S. Gascon-Shotkin, et al.. Higgs boson production via vectorlike top-partner decays: Diphoton or multilepton plus multijets channels at the LHC. Physical Review D, 2012, 85, pp.115022. ⟨10.1103/PhysRevD.85.115022⟩. ⟨in2p3-00712415⟩
  • F.D. Aaron, E. Barrelet, J.C. Bizot, V. Boudry, V. Brisson, et al.. Measurement of Beauty Photoproduction near Threshold using Di-electron Events with the H1 Detector at HERA. European Physical Journal C: Particles and Fields, 2012, 72, pp.2148. ⟨10.1140/epjc/s10052-012-2148-1⟩. ⟨in2p3-00711464⟩
  • H.M. Courtois, Y. Hoffman, R. Brent Tully, S. Gottlober. Three-dimensional velocity and density reconstructions of the Local unvierse with Cosmicflows-1. The Astrophysical Journal, 2012, 744, pp.43. ⟨10.1088/0004-637X/744/1/43⟩. ⟨in2p3-00631734⟩
  • J. Smeets, F. Roellinghoff, D. Prieels, F. Stichelbaut, A. Benilov, et al.. Prompt gamma imaging with a slit camera for real-time range control in proton therapy. Physics in Medicine and Biology, 2012, 57, pp.3371-3405. ⟨10.1088/0031-9155/57/11/3371⟩. ⟨in2p3-00709222⟩
  • A. Dijon, E. Clément, G. de France, G. de Angelis, G. Duchêne, et al.. Discovery of a new isomeric state in ^{68}Ni: Evidence for a highly-deformed proton intruder state.. Physical Review C, 2012, 85, pp.031301. ⟨10.1103/PhysRevC.85.031301⟩. ⟨in2p3-00674624⟩
  • D. Autiero. Neutrino Physics. CERN Italian Teachers Program, 2012, Genève, Switzerland. ⟨in2p3-01019684⟩

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