Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for a heavy pseudoscalar Higgs boson decaying into a 125 GeV Higgs boson and a Z boson in final states with two tau and two light leptons at \sqrt{s}= 13 TeV. JHEP, 2020, 03, pp.065. ⟨10.1007/JHEP03(2020)065⟩. ⟨hal-02371635⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Running of the top quark mass from proton-proton collisions at \sqrt{s} = 13TeV. Phys.Lett.B, 2020, 803, pp.135263. ⟨10.1016/j.physletb.2020.135263⟩. ⟨hal-02327849⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for physics beyond the standard model in events with jets and two same-sign or at least three charged leptons in proton-proton collisions at \sqrt{s}= 13 TeV. Eur.Phys.J.C, 2020, 80 (8), pp.752. ⟨10.1140/epjc/s10052-020-8168-3⟩. ⟨hal-02484007⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. The production of isolated photons in PbPb and pp collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. JHEP, 2020, 07, pp.116. ⟨10.1007/JHEP07(2020)116⟩. ⟨hal-02542892⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurements of \mathrm{t\bar{t}}H Production and the CP Structure of the Yukawa Interaction between the Higgs Boson and Top Quark in the Diphoton Decay Channel. Phys.Rev.Lett., 2020, 125 (6), pp.061801. ⟨10.1103/PhysRevLett.125.061801⟩. ⟨hal-02542843⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of the cross section for electroweak production of a Z boson, a photon and two jets in proton-proton collisions at \sqrt{s} = 13 TeV and constraints on anomalous quartic couplings. JHEP, 2020, 06, pp.076. ⟨10.1007/JHEP06(2020)076⟩. ⟨hal-02504651⟩
    • Jounghun Lee, Noam I. Libeskind, Suho Ryu. The Effect of Massive Neutrinos on the Halo Spin Flip Phenomenon. The Astrophysical Journal Letters, 2020, 898 (1), pp.L27. ⟨10.3847/2041-8213/aba2ee⟩. ⟨hal-02550026⟩
    • Elisabeth Daguenet, Safa Louati, Anne-Sophie Wozny, Nicolas Vial, Mathilde Gras, et al.. Radiation-induced bystander and abscopal effects: important lessons from preclinical models. British Journal of Cancer, 2020, 123 (3), pp.339-348. ⟨10.1038/s41416-020-0942-3⟩. ⟨hal-02927729⟩
    • Pierre Boldrini, Yohei Miki, Alexander Y. Wagner, Roya Mohayaee, Joseph Silk, et al.. Cusp-to-core transition in low-mass dwarf galaxies induced by dynamical heating of cold dark matter by primordial black holes. Monthly Notices of the Royal Astronomical Society, 2020, 492 (4), pp.5218-5225. ⟨10.1093/mnras/staa150⟩. ⟨hal-02361924⟩
    • Biagio Di Micco, Maxime Gouzevitch, Javier Mazzitelli, Caterina Vernieri, J. Alison, et al.. Higgs boson potential at colliders: Status and perspectives. Rev.Phys., 2020, 5, pp.100045. ⟨10.1016/j.revip.2020.100045⟩. ⟨hal-02327694⟩

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