Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Peng Diao, Yaoxiong Xia, et al.. Targeting stem cells by radiation: From the biological angle to clinical aspects . World Journal of Stem Cells, 2016, 8 (8), pp.243-250. ⟨10.4252/WJSC.v8.i8.243⟩. ⟨hal-01375903⟩
  • Nathalie Bonnin, Emma Armandy, Julien Carras, Sylvain Ferrandon, Priscillia Battiston-Montagne, et al.. MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma. Oncotarget, 2016, 7 (28), pp.44023-44038. ⟨10.18632/oncotarget.9829⟩. ⟨hal-01376219⟩
  • Anne-Sophie Wozny, Gersende Alphonse, Priscillia Battiston-Montagne, Stéphanie Simonet, Delphine Poncet, et al.. Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations. Frontiers in Oncology, 2016, 6 (58), ⟨10.3389/fonc.2016.00058⟩. ⟨hal-01376232⟩
  • Jean-Baptiste Guy, Chloé Rancoule, Benoîte Méry, Sophie Espenel, Anne-Sophie Wozny, et al.. Radiosensibilité et/ou résistance des cancers ORL : aspects biologiques. Bulletin du Cancer, 2016, 103 (1), pp.41-47. ⟨10.1016/j.bulcan.2015.10.016⟩. ⟨hal-01278015⟩
  • Chloé Rancoule, Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Yaoxiong Xia, et al.. Immunotherapy in head and neck cancer: Harnessing profit on a system disruption. Oral Oncology, 2016, 62, pp.153-162. ⟨10.1016/j.oraloncology.2016.09.002⟩. ⟨hal-01375889⟩
  • Marion Gilormini, Céline Malésys, Emma Armandy, Patrick Manas, Jean-Baptiste Guy, et al.. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. Oncotarget, 2016, 7 (13), pp.16731-16744. ⟨10.18632/oncotarget.7744⟩. ⟨hal-01376258⟩
  • Marion Gilormini, Anne-Sophie Wozny, Priscillia Battiston-Montagne, Dominique Ardail, Gersende Alphonse, et al.. Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics. Journal of visualized experiments : JoVE, 2016, pp.e53958. ⟨10.3791/53958⟩. ⟨hal-01277890⟩
  • Chloé Rancoule, Nicolas Magné, Alexis Vallard, Jean-Baptiste Guy, Claire Rodriguez-Lafrasse, et al.. Nanoparticles in radiation oncology: From bench-side to bedside. Cancer Letters, 2016, 375 (2), pp.256-262. ⟨10.1016/j.canlet.2016.03.011⟩. ⟨hal-01376249⟩
  • Benoîte Méry, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, Stéphanie Simonet, et al.. Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives. World Journal of Stem Cells, 2016, 8 (1), pp.13-21. ⟨10.4252/wjsc.v8.i1.13⟩. ⟨hal-01277977⟩
  • Sylvain Ferrandon, Badia El Hamdani, Sophie Gazzo, Priscillia Battiston-Montagne, Michael Beuve, et al.. Carbon ions Versus γ-Irradiation: The Telomeric Effect in Cancer Cells. Jacobs Journal of Radiation Oncology, 2016, 3 (3), pp.031. ⟨hal-01450160⟩

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