Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy. Physical Review Letters, 2012, 109, pp.071803. ⟨10.1103/PhysRevLett.109.071803⟩. ⟨in2p3-00702658⟩
  • V.M. Abazov, H. Li, G. Sajot, J. Stark, S. Greder, et al.. Search for the standard model Higgs boson in associated WH production in 9.7 fb^{-1} of p\bar{p} collisions with the D0 detector. Physical Review Letters, 2012, 109, pp.121804. ⟨10.1103/PhysRevLett.109.121804⟩. ⟨in2p3-00722870⟩
  • M. Bonnaffé-Moity, A. Ouadi, V. Mazan, S. Miroshnichenko, D. Ternova, et al.. Comparison of uranyl extraction mechanisms in an ionic liquid by use of malonamide or malonamide-functionalized ionic liquid. Dalton Transactions, 2012, 41, pp.7526-7536. ⟨10.1039/C2DT12421A⟩. ⟨in2p3-00711076⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Ratios of dijet production cross sections as a function of the absolute difference in rapidity between jets in proton-proton collisions at sqrt(s) = 7 TeV. European Physical Journal C: Particles and Fields, 2012, 72, pp.2216. ⟨10.1140/epjc/s10052-012-2216-6⟩. ⟨in2p3-00685081⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for microscopic black holes in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2012, 4, pp.61. ⟨10.1007/JHEP04(2012)061⟩. ⟨in2p3-00675416⟩
  • V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Search for Higgs boson production in oppositely charged dilepton and missing energy events in {p\bar{p}} collisions at {\sqrt{s} =}1.96 TeV. Physical Review D, 2012, 86, pp.032010. ⟨10.1103/PhysRevD.86.032010⟩. ⟨in2p3-00714577⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Centrality dependence of dihadron correlations and azimuthal anisotropy harmonics in PbPb collisions at sqrt(s[NN]) = 2.76 TeV. European Physical Journal C: Particles and Fields, 2012, 72, pp.2012. ⟨10.1140/epjc/s10052-012-2012-3⟩. ⟨in2p3-00660549⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Suppression of non-prompt J/psi, prompt J/psi, and Y(1S) in PbPb collisions at sqrt(sNN) = 2.76 TeV. Journal of High Energy Physics, 2012, 05, pp.063. ⟨10.1007/JHEP05(2012)063⟩. ⟨in2p3-00662872⟩
  • I. Billard, A. Ouadi, C. Gaillard, V. Kalchenko, D. Ternova. Open questions for liquid/liquid extraction of ions with the help of ionic liquids. 6th International Symposium "Supramolecular Systems in Chemistry and Biology", 2012, Strasbourg, France. ⟨in2p3-01018438⟩
  • V.M. Abazov, H. Li, G. Sajot, J. Stark, S. Greder, et al.. Search for Zgamma events with large missing transverse energy in ppbar collisions at sqrt(s)=1.96 TeV. Physical Review D, 2012, 86, pp.071701(R). ⟨10.1103/PhysRevD.86.071701⟩. ⟨in2p3-00682424⟩

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