Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Bruny, S. Eden, S. Feil, R. Fillol, K. El Farkh, et al.. A new experimental setup designed for the investigation of irradiation of nanosystems in the gas phase: A high intensity mass-and-energy selected cluster beam. Review of Scientific Instruments, 2012, 83, pp.013305. ⟨10.1063/1.3677845⟩. ⟨in2p3-00662390⟩
  • Ze-Kun Guo, S. Narison, J.-M. Richard, Qiang Zhao. Isospin violating decay of \psi(3770)\rightarrow J/\psi + \pi^0. Physical Review D, 2012, 85, pp.114007. ⟨10.1103/PhysRevD.85.114007⟩. ⟨in2p3-00686368⟩
  • A. Arbey, M. Battaglia, A. Djouadi, F. Mahmoudi, J. Quevillon. Implications of a 125 GeV Higgs for supersymmetric models. Physics Letters B, 2012, 708, pp.162-169. ⟨10.1016/j.physletb.2012.01.053⟩. ⟨in2p3-00651671⟩
  • G. Brooijmans, B. Gripaios, F. Moortgat, J. Santiago, P. Skands, et al.. Les Houches 2011: Physics at TeV Colliders New Physics Working Group Report. [Research Report] IN2P3. 2012, 243 p. ⟨in2p3-00677468⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for the standard model Higgs boson decaying to bottom quarks in pp collisions at sqrt(s)=7 TeV. Physics Letters B, 2012, 710, pp.284-306. ⟨10.1016/j.physletb.2012.02.085⟩. ⟨in2p3-00672303⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Measurement of the Rapidity and Transverse Momentum Distributions of Z Bosons in pp Collisions at sqrt(s)=7 TeV. Physical Review D, 2012, 85, pp.032002. ⟨10.1103/PhysRevD.85.032002⟩. ⟨in2p3-00635304⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for exclusive or semi-exclusive photon pair production and observation of exclusive and semi-exclusive electron pair production in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2012, 11(2012), pp.080. ⟨10.1007/JHEP11(2012)080⟩. ⟨in2p3-00730762⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for heavy lepton partners of neutrinos in proton-proton collisions in the context of the type III seesaw mechanism. Physics Letters B, 2012, 718, pp.348-368. ⟨10.1016/j.physletb.2012.10.070⟩. ⟨in2p3-00739346⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Forward Energy Flow, Central Charged-Particle Multiplicities, and Pseudorapidity Gaps in W and Z Boson Events from pp Collisions at 7 TeV. European Physical Journal C: Particles and Fields, 2012, 72, pp.1839. ⟨10.1140/epjc/s10052-011-1839-3⟩. ⟨in2p3-00628687⟩
  • V. M. Abazov, M. C. Cousinou, A. Duperrin, W. Geng, E. Kajfasz, et al.. Search for the standard model Higgs boson in the ZH->vvbb channel in 9.5 fb-1 of ppbar collisions at sqrt(s) = 1.96 TeV. Physics Letters B, 2012, 716, pp.285-293. ⟨10.1016/j.physletb.2012.08.034⟩. ⟨in2p3-00720591⟩

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