Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- O. Stézowski. Data Analysis. European Gamma and Ancillary Detector Network (EGAN) school, 2012, Darmstadt, Germany. ⟨in2p3-01018628⟩
- H.M. Courtois, R. Brent Tully. Cosmicflows-2: SNIa Calibration and H0. The Astrophysical Journal, 2012, 49, pp.174. ⟨10.1088/0004-637X/749/2/174⟩. ⟨in2p3-00672005⟩
- R. Bes, S. Gavarini, N. Millard-Pinard, Sandrine Cardinal, A. Perrat-Mabilon, et al.. Influence of crystallographic orientation on the early stages of oxidation of polycrystalline titanium nitride. Journal of Nuclear Materials, 2012, 427, pp.415-417. ⟨10.1016/j.jnucmat.2012.03.031⟩. ⟨in2p3-00730940⟩
- H. Abdoul-Carime, M. Harb, C.G. Montano, C. Teyssier, B. Farizon, et al.. Selective host-guest chemistry investigated by mass spectrometry: Which of the two, choline or acetylcholine, is the preferred one by the 3iPO triphosphonate-cavitand?. Chemical Physics Letters, 2012, 533, pp.82-86. ⟨10.1016/j.cplett.2012.02.066⟩. ⟨in2p3-00691934⟩
- Sacha Davidson, P. Verdier. LHC sensitivity to the decay of a Higgs boson to tau mu. Physical Review D, 2012, 86, pp.111701(R). ⟨10.1103/PhysRevD.86.111701⟩. ⟨in2p3-00749209⟩
- B. Abelev, N. Arbor, G. Conesa Balbastre, J. Faivre, C. Furget, et al.. Pion, Kaon, and Proton Production in Central Pb--Pb Collisions at
TeV. Physical Review Letters, 2012, 109, pp.252301. ⟨10.1103/PhysRevLett.109.252301⟩. ⟨in2p3-00723478⟩ - B. Abelev, J. Adam, D. Adamova, A. M. Adare, M. M. Aggarwal, et al.. Inclusive J/psi production in pp collisions at sqrt(s) = 2.76 TeV. Physics Letters B, 2012, 718, pp.295-306. ⟨10.1016/j.physletb.2012.10.078⟩. ⟨in2p3-00680363⟩
- B. Abelev, N. Arbor, G. Conesa Balbastre, J. Faivre, C. Furget, et al.. Neutral pion and
meson production in proton-proton collisions at 
TeV and 
TeV. Physics Letters B, 2012, 717, pp.162-172. ⟨10.1016/j.physletb.2012.09.015⟩. ⟨in2p3-00703615⟩ - G. Cacciapaglia. LHC missing-transverse-energy constraints on models with universal extra dimensions. GDR Terascale meeting GDR Terascale@Montpellier, 2012, Montpellier, France. ⟨in2p3-00982036⟩
- F. K. Röpke, M. Kromer, I. R. Seitenzahl, R. Pakmor, S. A. Sim, et al.. Constraining Type Ia Supernova Models: SN 2011fe as a Test Case. The Astrophysical Journal Letters, 2012, 750, pp.L19. ⟨10.1088/2041-8205/750/1/L19⟩. ⟨in2p3-00690635⟩
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