Health

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

SAADE Gaëlle

8786 documents

V.M. Abazov, S. Greder, F. Miconi, I. Ripp-Baudot, G. Bernardi, et al.. Limits on anomalous trilinear gauge boson couplings from WW, WZ and Wgamma production in pp-bar collisions at sqrt{s}=1.96 TeV. Physics Letters B, 2012, 718, pp.451-459. ⟨10.1016/j.physletb.2012.10.062⟩. ⟨in2p3-00727400⟩
V.M. Abazov, H. Li, G. Sajot, J. Stark, S. Greder, et al.. Measurement of the W Boson Mass with the D0 Detector. Physical Review Letters, 2012, 108, pp.151804. ⟨10.1103/PhysRevLett.108.151804⟩. ⟨in2p3-00675833⟩
S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for third-generation leptoquarks and scalar bottom quarks in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2012, 12, pp.055. ⟨10.1007/JHEP12(2012)055⟩. ⟨in2p3-00744369⟩
F.D. Aaron, E. Barrelet, J.C. Bizot, V. Brisson, B. Delcourt, et al.. Measurement of Beauty and Charm Photoproduction using Semi-muonic Decays in Dijet Events at HERA. European Physical Journal C: Particles and Fields, 2012, 72, pp.2047. ⟨10.1140/epjc/s10052-012-2047-5⟩. ⟨in2p3-00716954⟩
J. Sadoudi, M. Bender, K. Bennaceur, D. Davesne, R. Jodon, et al.. Skyrme pseudo-potential-based EDF parametrisation for spuriousity-free MR-EDF calculations. XIX Nuclear Physics Workshop "Marie & Pierre Curie", 2012, Kazimierz Dolny, Poland. pp.014013, ⟨10.1088/0031-8949/2013/T154/014013⟩. ⟨in2p3-00750292⟩
S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Measurement of the top quark pair production cross section in pp collisions at sqrt(s) = 7 TeV in dilepton final states containing a tau. Physical Review D, 2012, 85, pp.112007. ⟨10.1103/PhysRevD.85.112007⟩. ⟨in2p3-00684399⟩
S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Measurement of the underlying event in the Drell-Yan process in proton-proton collisions at sqrt(s) = 7 TeV. European Physical Journal C: Particles and Fields, 2012, 72, pp.2080. ⟨10.1140/epjc/s10052-012-2080-4⟩. ⟨in2p3-00736378⟩
S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Combined search for the quarks of a sequential fourth generation. Physical Review D, 2012, 86, pp.112003. ⟨10.1103/PhysRevD.86.112003⟩. ⟨in2p3-00730454⟩
V.M. Abazov, U. Bassler, G. Bernardi, D. Brown, J. Brown, et al.. Measurement of the photon $+b$ -jet production differential cross section in $p\bar{p}$ collisions at $\sqrt{s}=1.96~\TeV$ . Physics Letters B, 2012, 714, pp.32-39. ⟨10.1016/j.physletb.2012.06.056⟩. ⟨in2p3-00683164⟩
V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Evidence for spin correlation in ttbar production. Physical Review Letters, 2012, 108, pp.032004. ⟨10.1103/PhysRevLett.108.032004⟩. ⟨in2p3-00634051⟩

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