Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Autiero. Measurement of the Neutrino Velocity with the OPERA Detector in the CNGS Beam. APC Meeting on Superluminal Neutrinos, Jan 2012, Paris, France. ⟨in2p3-01000960⟩
  • V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Search for the standard model Higgs boson in tau lepton final states. Physics Letters B, 2012, 714, pp.237-245. ⟨10.1016/j.physletb.2012.07.012⟩. ⟨in2p3-00681225⟩
  • I. Billard, A. Ouadi, C. Gaillard. Extraction of metal ions by Ionic Liquids: toward a general model. International Symposium on Metal Complexes, 2012, Lisbonne, Portugal. ⟨in2p3-01018436⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for dark matter and large extra dimensions in monojet events in pp collisions at sqrt(s)= 7 TeV. Journal of High Energy Physics, 2012, 9, pp.94. ⟨10.1007/JHEP09(2012)094⟩. ⟨in2p3-00711873⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for a light charged Higgs boson in top quark decays in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2012, 07(2012), pp.143. ⟨10.1007/JHEP07(2012)143⟩. ⟨in2p3-00757184⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Observation of Z decays to four leptons with the CMS detector at the LHC. Journal of High Energy Physics, 2012, 12, pp.034. ⟨10.1007/JHEP12(2012)034⟩. ⟨in2p3-00742132⟩
  • V.M. Abazov, H. Li, G. Sajot, J. Stark, S. Greder, et al.. Measurement of the top quark mass in p \bar{p} collisions using events with two leptons. Physical Review D, 2012, 86, pp.051103. ⟨10.1103/PhysRevD.86.051103⟩. ⟨in2p3-00663077⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for pair production of first- and second-generation scalar leptoquarks in pp collisions at sqrt(s)= 7 TeV. Physical Review D, 2012, 86, pp.052013. ⟨10.1103/PhysRevD.86.052013⟩. ⟨in2p3-00720190⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Measurement of the pseudorapidity and centrality dependence of the transverse energy density in PbPb collisions at sqrt(s[NN]) = 2.76 TeV. Physical Review Letters, 2012, 109, pp.152303. ⟨10.1103/PhysRevLett.109.152303⟩. ⟨in2p3-00696813⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for new physics in events with same-sign dileptons and b-tagged jets in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2012, 8, pp.110. ⟨10.1007/JHEP08(2012)110⟩. ⟨in2p3-00705649⟩

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