Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • C. Bâty, O. Bondu, H. Brun, G. Chen, S. Gascon-Shotkin, et al.. Photon energy scale Study of radiative Z0 decays in the CMS experiment. 5th Workshop of the France China Particle Physics Laboratory FCPPL 2012, Mar 2012, Orsay, France. ⟨in2p3-01010587⟩
  • G. Alphonse, N.H. Hau, P. Heudel, P. Battiston-Montagne, D. Poncet, et al.. Predictives markers of intrasic radiosensitivity in human glioma cells lines irradiated with photon or carbon ions. 7èmes JournĂ©es Scientifiques du CancĂ©ropĂ´le CLARA, Mar 2012, Lyon, France. ⟨hal-00840296⟩
  • G. Bertrand, M. Maalouf, A. Boivin, P. Battiston-Montagne, M. Beuve, et al.. Molecular mechanism of tumor cell radioresistance in head and neck squamous cell carcinos. 7èmes JournĂ©es Scientifiques du CancĂ©ropĂ´le CLARA, Mar 2012, Lyon, France. ⟨hal-00839205⟩
  • S. Gascon-Shotkin. Photon Production at Ecm=7 TeV. Rencontres de Moriond QCD and High Energy Interactions (Moriond QCD 2012), Mar 2012, La Thuile, Italy. ⟨in2p3-00967846⟩
  • Hugues Brun. La reconstruction et l'identification des photons dans l'expĂ©rience CMS au LHC. Applications Ă  la recherche de bosons de Higgs dans le canal H \rightarrow \gamma\gamma. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2012. Français. ⟨NNT : ⟩. ⟨tel-00916276⟩
  • Gianguido Baldinozzi, David Simeone, Dominique Gosset, Laurence LunĂ©ville, Lionel Desgranges, et al.. Radiation Effects in Ceramics: Ceramics dislike strain, so they react to adapt. Radiation Effects and Materials Development Workshop, Feb 2012, Menai, NSW, Australia. ⟨hal-00678229⟩
  • M. de Rydt, M. Chevallier, D. Dauvergne, S. Deng, G. Dedes, et al.. REAL-TIME MONITORING OF THE BRAGG PEAK DURING ION THERAPY: RECENT DEVELOPMENTS OF THE BEAM DETECTION SYSTEM. ICTR-PHE 2012 Conference, Feb 2012, Genève, Switzerland. pp.S60-S61, ⟨10.1016/S0167-8140(12)70108-1⟩. ⟨hal-00990830⟩
  • E. Testa, M. Chevallier, D. Dauvergne, G. Dedes, M. de Rydt, et al.. SPATIAL CORRELATIONS BETWEEN IMAGES DERIVED FROM DYNAMIC FDG-PET. ICTR-PHE 2012 Conference, Feb 2012, Genève, Switzerland. pp.S122-S123, ⟨10.1016/S0167-8140(12)70207-4⟩. ⟨hal-00990834⟩
  • E. Testa, D. Dauvergne, G. Dedes, N. Freud, P. Henriquet, et al.. Interaction vertex imaging (IVI) for carbon ion therapy monitoring: a feasibility study. ICTR-PHE 2012, Feb 2012, Genève, Switzerland. ⟨hal-01118823⟩
  • I. Billard, A. Ouadi, C. Gaillard. A universal model for An liquid/liquid extraction in ionic liquids. SESTEC Conference, Feb 2012, Mumbai, India. ⟨in2p3-01018433⟩

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