Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • K. Bennaceur. New generation of Skyrme energy density functionals for nuclear matter and finite nuclei. CompStar: the physics and astrophysics of compact stars, Jun 2012, Tahiti, French Polynesia. ⟨in2p3-00978614⟩
  • O. Stézowski. AGATA Data Analysis Status Report. AGATA Week, Jun 2012, Darmstadt, Germany. ⟨in2p3-01018618⟩
  • M. Gherrab, N. Millard-Pinard, S. Gavarini, V. Garnier. Elaboration et caractérisation de carbure de titane nano et microstructurés. ARC ENERGIE, Jun 2012, Lyon, France. ⟨in2p3-01018586⟩
  • M. Martini, M. Ericson. Neutrino energy reconstruction problems and neutrino oscillations. 11th Conference on the intersections of particle and nuclear physics (CIPANP 2012), May 2012, St. Petersburg, FL, United States. pp.220, ⟨10.1063/1.4826758⟩. ⟨in2p3-00983323⟩
  • R. Chehab. Research on a new crystal-assisted positron source for the ILC. Joint workshop of the France Japan and France Korea Particle Physics Laboratories (TYL-FKPPL), May 2012, Clermont-Ferrand, France. ⟨in2p3-01012123⟩
  • M. Gouzevitch, U. Virginia. Simulation of the CMS detector for the high luminosity upgrade. CMS Workshop: Perspectives on Physics and on CMS at Very High Luminosity, HL-LHC, May 2012, Alushta, Crimea, Ukraine. ⟨in2p3-00921099⟩
  • B. Borderie, E. Galichet, M.F. Rivet, S. Piantelli, Ad.R. Raduta, et al.. The behaviour of constrained caloric curves as ultimate signature of a phase transition for hot nuclei. 11th International Conference on Nucleus-Nucleus Collisions (NN2012), May 2012, San Antonio, Texas, United States. pp.012081, ⟨10.1088/1742-6596/420/1/012081⟩. ⟨hal-00720759⟩
  • A. Uras. Dimuon measurements in ALICE: The Muon Forward Tracker Upgrade Project. 5th International Conference on Hard and Electromagnetic Probes High-Energy Nuclear Collisions Hard Probes 2012, May 2012, Cagliari, Italy. ⟨in2p3-01019681⟩
  • H. Ladjal, J. Saade, M. Beuve, Joseph Azencot, J.-M. Moreau, et al.. 3D Biomechanical Modeling of the Human Diaphragm Based on CT Scan Images. World Congress on Medical Physics and Biomedical Engineering, May 2012, Beijing, China. pp.2188-2191, ⟨10.1007/978-3-642-29305-4_574⟩. ⟨hal-01118208⟩
  • D. Autiero. Measurement of the neutrino velocity with the OPERA detector in the CNGS beam. Ecole doctorale de physique et sciences de la matière de l'Université d'Aix-Marseille, May 2012, Marseille, France. ⟨in2p3-01019687⟩

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