Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • F. Marmol, C. Cerna, A. Castera, A. Ealet. Comparison of hybrid and SIDECAR ASIC measurements. High Energy, Optical, and Infrared Detectors for Astronomy V, Jul 2012, Amsterdam, Netherlands. 8453, pp.845330, 2012, ⟨10.1117/12.926995⟩. ⟨in2p3-00716787⟩
  • E. Prieto, J. Amiaux, J.-L. Auguères, J.-C. Barrière, C. Bonoli, et al.. Euclid near-infrared spectrophotometer instrument concept at the end of the phase A study. Space Telescopes and Instrumentation 2012: Optical, Infrared, and Millimeter Wave, Jul 2012, Amsterdam, Netherlands. pp.8442-29. ⟨in2p3-00716724⟩
  • C. Cerna, J. C. Clémens, A. Ealet, G. Smadja, A. Castera, et al.. The EUCLID NISP Detectors System. High Energy, Optical, and Infrared Detectors for Astronomy V, Jul 2012, Amsterdam, Netherlands. pp.8453-36. ⟨in2p3-00716799⟩
  • Timur Doumler. Constrained local universe simulations from galaxy peculiar velocities. Other. Université Claude Bernard - Lyon I; Universität Potsdam, 2012. English. ⟨NNT : 2012LYO10076⟩. ⟨tel-01127294⟩
  • D. Boutin, N. Kazarinov, F.R. Osswald, C. Peaucelle, T. Thuillier. The RIB dynamics of the SPIRAL 2 transfer line. 12th International Conference on Heavy Ion Accelerator Technology (HIAT 2012), Jun 2012, Chicago, United States. Joint Accelerator Conferences Website, pp.54-57, 2012. ⟨in2p3-00712764⟩
  • J. Colin, D. Cussol, J. Dudouet, J.M. Fontbonne, M. Labalme, et al.. 95MeV/u 12C nuclear fragmentation measurements on thin targets for hadrontherapy. The 13th International Conference on Nuclear Reaction Mechanisms, Jun 2012, Varenna, Italy. pp.459-460. ⟨in2p3-00855256⟩
  • P. Manescu, Joseph Azencot, M. Beuve, H. Ladjal, J. Saadé, et al.. Material density mapping on deformable 3D models of human organs. ICBBE 2012 : International Conference on Biomechanics and Biomedical Engineering, Jun 2012, Copenhagen, Denmark. pp.131-140. ⟨hal-00838834⟩
  • M. Gouzevitch. QCD at the CMS. International Conference on New Frontiers in Physics - ICFP 2012, Jun 2012, Kolymbari, Crète, Greece. ⟨in2p3-00967864⟩
  • G. Moretto, I. Vauglin, M. Langlois, N. Epchtein. An Off-Axis Telescope Concept for Antarctic Astronomy. Semaine de l'Astrophysique Française, Jun 2012, Nice, France. ⟨in2p3-00741375⟩
  • E. Bechetoille. Electronique front-end basse température pour TPC à argon liquide. VLSI FPGA IAO/CAO, Jun 2012, Villeurbanne, France. ⟨in2p3-01019685⟩

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