Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Deng, D. Dauvergne, G.-N. Lu, H. Mathez, Y. Zoccarato. Very fast front end ASIC associated with multi anode PMT for a scintillating-fibre beam hodoscope. TWEPP 2012 Topical Workshop on Electronics for Particle Physics, Sep 2012, Oxford, United Kingdom. p. 2013 JINST 8 C01047. ⟨hal-00842813⟩
  • D. Poncet, S. Ferrandon, P. Saultier, J. Carras, P. Battiston-Montagne, et al.. Statut télomérique : vers un traitement personnalisé du glioblastome. Journées d'automne de l'ANPMCB, Sep 2012, Lyon, France. ⟨hal-00841305⟩
  • Marie-Hélène Richard. Design study of a Compton camera for prompts-gamma imaging during ion beam therapy. Other [cond-mat.other]. Université Claude Bernard - Lyon I, 2012. English. ⟨NNT : 2012LYO10124⟩. ⟨tel-00934715⟩
  • G. Moretto, Jeff R. Kuhn, Phil R. Goode. Reviewing off-axis telescope concepts A quest for highest possible dynamic range for photometry and angular resolution. Proceedings of SPIE, the International Society for Optical Engineering, 2012, 8444, pp.8444OY. ⟨10.1117/12.926780⟩. ⟨in2p3-00740920⟩
  • G. Moretto, Nicolas Epchtein, Maud Langlois, Isabelle Vauglin. An Off-Axis Telescope Concept for Antarctic Astronomy. Proceedings of SPIE, the International Society for Optical Engineering, 2012, 8444, pp.84445E. ⟨10.1117/12.927257⟩. ⟨in2p3-00740937⟩
  • D. Krasnický, L. Cabaret, D. Comparat, P. Nédélec. AEgIS Experiment Commissioning at CERN. 10th International Workshop on Non-Neutral Plasmas, Aug 2012, Greifswald, Germany. pp.144-153, ⟨10.1063/1.4796070⟩. ⟨in2p3-01007693⟩
  • D. Pomarede, H.M. Courtois, R. Brent Tully. Visualization of structures and cosmic flows in the Local Universe. Advancing the Physics of Cosmic Distances, Aug 2012, Beijing, China. pp.323-326. ⟨in2p3-00835758⟩
  • J.-M. Richard. The Role of Flavor in Multiquark Spectroscopy. International Workshop on Strangeness Nuclear Physics (SNP12), Aug 2012, Osaka, Japan. ⟨in2p3-00768198⟩
  • L. Abe, N. Epchtein, W. Ansorge, S. Argentini, I. Bryson, et al.. A European vision for a "Polar Large Telescope'' project. Astrophysics from Antarctica, Proceedings of the International Astronomical Union, IAU Symposium, Aug 2012, Beijing, China. pp.243-250, ⟨10.1017/S174392131201695X⟩. ⟨in2p3-00866778⟩
  • Maurice Robert Kibler, Mohammed Daoud. PHASE STATES AND COHERENT STATES FOR GENERALIZED WEYL-HEISENBERG ALGEBRAS. The XXIXth International Colloquium on Group-Theoretical Methods in Physics, Aug 2012, Tianjin, China. ⟨in2p3-00741945⟩

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