Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Uras. Muon Physics in ALICE: The MFT Upgrade Project. Hot Quarks 2012: Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus Collisions, Oct 2012, Copamarina, Puerto Rico. pp.012054, ⟨10.1088/1742-6596/446/1/012054⟩. ⟨in2p3-01018974⟩
  • Olivier Bondu. Etude des dĂ©sintĂ©grations radiatives Z^0 \rightarrow \mu\mu\gamma et recherches du boson de Higgs dans le canal H\rightarrow \gamma\gamma dans l'expĂ©rience CMS au LHC (CERN). Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2012. Français. ⟨NNT : ⟩. ⟨tel-00914252⟩
  • Olivier Bondu. Étude des dĂ©sintĂ©grations radiatives Z →μμγ et recherches du boson de Higgs dans le canal H→γγ dans l’expĂ©rience CMS au LHC (CERN). Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2012. Français. ⟨NNT : 2012LYO10198⟩. ⟨tel-01817022v2⟩
  • M. Gouzevitch. CMS photons and jets measurements overview. PDF4LHC Workshop, Oct 2012, Genève, Switzerland. ⟨in2p3-00972025⟩
  • Bogna Kubik. Electroweak symmetry breaking in the light of LHC. Physics [physics]. UniversitĂ© Claude Bernard - Lyon I, 2012. English. ⟨NNT : 2012LYO10136⟩. ⟨tel-00770109v2⟩
  • S. Ferrandon, P. Saultier, J. Carras, P. Battiston-Montagne, G. Alphonse, et al.. Telomere profiling : toward glioblastoma personalized medicine. The EMBO Telomeres and the DDR Meeting, Oct 2012, Isles sur Sorgues, France. ⟨hal-00842488⟩
  • L. Chollier. ModĂ©lisation biophysique de l'interaction des ions de hautes Ă©nergies avec la matière vivante : application aux traitements de tumeurs par hadronthĂ©rapie. 2012. ⟨hal-00949681⟩
  • M.-H. Richard, M. Dahoumane, D. Dauvergne, M. de Rydt, G. Dedes, et al.. Design Study of the Absorber Detector of a Compton Camera for On-Line Control in Ion Beam Therapy. IEEE Transactions on Nuclear Science, 2012, 59 (5), pp.1850-1855. ⟨10.1109/TNS.2012.2206053⟩. ⟨hal-00796857⟩
  • CĂ©cile Teyssier. SpectromĂ©trie de masse COINTOF : Conception et d'un analyseur Ă  temps de vol et dĂ©veloppement de la mĂ©thode d'analyse. Autre [cond-mat.other]. UniversitĂ© Claude Bernard - Lyon I, 2012. Français. ⟨NNT : 2012LYO10148⟩. ⟨tel-00744850v2⟩
  • T. Thuillier, J. Angot, T. Lamy, M. Marie-Jeanne, C. Peaucelle, et al.. Recent results of PHOENIX V2 and new prospects with PHOENIX V3. 20th International Workshop on Electron Cyclotron Resonance Ion Sources (ECRIS-2012), Sep 2012, Sydney, Australia. pp.117-1220. ⟨in2p3-00847236⟩

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