Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Cacciapaglia. Dark Matter in a Twisted bottle. GDR Terascale Meeting GDR Terascale@Paris, Nov 2012, Paris, France. ⟨in2p3-01025059⟩
  • I. Laktineh. Construction and Commissioning of a an Ultra-Granular Hadronic Calorimeter Prototype. 2012 Nuclear Science Symposium, Medical Imaging Conference & Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors (2012 IEEE NSS/MIC/RTSD), Oct 2012, Anaheim, United States. ⟨in2p3-00747336⟩
  • G. Dedes, D. Dauvergne, M. de Rydt, N. Freud, J. Krimmer, et al.. Monte Carlo Nuclear Models Evaluation and Improvements for Real-Time Prompt Gamma-Ray Monitoring in Proton and Carbon Therapy. 2012 Nuclear Science Symposium, Medical Imaging Conference & Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors (2012 IEEE NSS/MIC/RTSD), Oct 2012, Anaheim, United States. ⟨in2p3-00747340⟩
  • Nathalie Destouches, Y. Battie, N. Crespo-Monteiro, F. Chassagneux, L. Bois, et al.. Photo-directed Organization of Silver Nanoparticles in Mesostructured Silica and Titania Films. Journal of Nanoparticle Research, 2012, 15, pp.1422. ⟨10.1007/s11051-013-1422-y⟩. ⟨ujm-00734236⟩
  • E. Testa, L. Balleyguier, J. Baudot, S. Brons, L. Caponetto, et al.. Real-time Online Monitoring of the Ion Range by means of Prompt Secondary Radiations. 2012 Nuclear Science Symposium, Medical Imaging Conference & Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors, Oct 2012, Anaheim, United States. pp.NA. ⟨hal-00840429⟩
  • M. de Rydt, S. Deng, D. Dauvergne, G. Dedes, N. Freud, et al.. Real-Time Monitoring During Ion Therapy: Development and Evaluation of a Beam Hodoscope and Its Dedicated Electronics. 2012 Nuclear Science Symposium, Medical Imaging Conference & Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors, Oct 2012, Anaheim, United States. pp.NA. ⟨hal-00840418⟩
  • P. Gueth, L. Grevillot, D. Dauvergne, N. Freud, J.-M. Létang, et al.. Gate simulation of a complete proton treatment combined with prompt-gamma monitoring. 2012 Nuclear Science Symposium, Medical Imaging Conference, Oct 2012, Anaheim, United States. ⟨hal-00838620⟩
  • K. Bennaceur. Linear response method for the construction of new EDF's. FIDIPRO miniworkshop on "Nulcear single-particle states and correlation", Oct 2012, Jyvaskyla, Finland. ⟨in2p3-00978616⟩
  • G. Dedes, S. Rit, D. Dauvergne, M. de Rydt, N. Freud, et al.. Electron density resolution determination and systematic uncertainties in proton computed tomography (pcT). IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Oct 2012, Anaheim, United States. ⟨10.1109/NSSMIC.2012.6551586⟩. ⟨hal-01149111⟩
  • M. Dahoumane, D. Dauvergne, J. Krimmer, H. Mathez, C. Ray, et al.. A Low Noise and High Dynamic Charge Sensitive Amplifier-Shaper associated with Silicon Strip Detector for Compton Camera in hadrontherapy. 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference (2012 NSS/MIC), Oct 2012, Anaheim, California, United States. ⟨10.1109/NSSMIC.2012.6551351⟩. ⟨in2p3-00753748⟩

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