Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • C. Aidala, Y. Akiba, M. Alfred, V. Andrieux, N. Apadula, et al.. Nuclear-modification factor of charged hadrons at forward and backward rapidity in p+Al and p+Au collisions at \sqrt{s_{_{NN}}}=200 GeV. Physical Review C, 2020, 101 (3), pp.034910. ⟨10.1103/PhysRevC.101.034910⟩. ⟨hal-02178556⟩
    • Peng Wang, Noam I. Libeskind, Elmo Tempel, Marcel S. Pawlowski, Xi Kang, et al.. The Alignment of Satellite Systems with Cosmic Filaments in the SDSS DR12. The Astrophysical Journal, 2020, 900 (2), pp.129. ⟨10.3847/1538-4357/aba6ea⟩. ⟨hal-02922211⟩
    • N. Mărginean, D. Little, Y. Tsunoda, S. Leoni, R.V.F. Janssens, et al.. Shape Coexistence at Zero Spin in ^{64}\mathrm{Ni} Driven by the Monopole Tensor Interaction. Physical Review Letters, 2020, 125 (10), pp.102502. ⟨10.1103/PhysRevLett.125.102502⟩. ⟨hal-03186279⟩
    • U.A. Acharya, A. Adare, C. Aidala, N.N. Ajitanand, Y. Akiba, et al.. Measurement of charged pion double spin asymmetries at midrapidity in longitudinally polarized p+p collisions at \sqrt {s} = 510 GeV. Physical Review D, 2020, 102 (3), pp.032001. ⟨10.1103/PhysRevD.102.032001⟩. ⟨hal-02628786⟩
    • U. Acharya, A. Adare, C. Aidala, N.N. Ajitanand, Y. Akiba, et al.. Measurement of J/\psi at forward and backward rapidity in p+p, p+Al, p+Au, and ^3He+Au collisions at \sqrt{s_{_{NN}}}=200~{\rm GeV}. Physical Review C, 2020, 102 (1), pp.014902. ⟨10.1103/PhysRevC.102.014902⟩. ⟨hal-03143744⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Measurement of nuclear effects on \psi\rm{(2S)} production in p-Pb collisions at \sqrt{\textit{s}_{\rm NN}} = 8.16 TeV. Journal of High Energy Physics, 2020, 07, pp.237. ⟨10.1007/JHEP07(2020)237⟩. ⟨hal-02527038⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Multiplicity dependence of J/\psi production at midrapidity in pp collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2020, 810, pp.135758. ⟨10.1016/j.physletb.2020.135758⟩. ⟨hal-02863129⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Search for a common baryon source in high-multiplicity pp collisions at the LHC. Phys.Lett.B, 2020, 811, pp.135849. ⟨10.1016/j.physletb.2020.135849⟩. ⟨hal-02564584⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of electrons from heavy-flavour hadron decays as a function of multiplicity in p-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Journal of High Energy Physics, 2020, 02, pp.077. ⟨10.1007/JHEP02(2020)077⟩. ⟨hal-02383420⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Dielectron production in proton-proton and proton-lead collisions at \sqrt{s_{NN}}= 5.02 TeV. Physical Review C, 2020, 102 (5), pp.055204. ⟨10.1103/PhysRevC.102.055204⟩. ⟨hal-02863144⟩

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