Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • Michael Beuve. Modeling of Tumor Control Probability for Hadrontherapy. Hadrontherapy school - CNAO, France Hadron, LabEx PRIMES, Sep 2016, Pavia, Italy. ⟨hal-01916495⟩
  • Anne-Sophie Wozny, Alexandra Lauret, Yannick Saintigny, Priscillia Battiston-Montagne, Michael Beuve, et al.. A key role of HIF-1α in the radioresistance of Cancer Stem Cells in their hypoxic microenvironment. 42nd Conference on the European radiation research society (ERR 2016), Sep 2016, Amsterdam, Netherlands. ⟨hal-01400307⟩
  • Claire Rodriguez-Lafrasse. Nanoparticules radiosensibilisantes : rĂŞve d’hier, rĂ©alitĂ© de demain. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01297925⟩
  • Jean-Baptiste Guy, BenoĂ®te MĂ©ry, Anne-Sophie Wozny, Priscillia Battiston-Montagne, Dominique Ardail, et al.. Ciblage de la famille HER dans les cancers ORL : inhibition de la prolifĂ©ration cellulaire et de l’invasion-migration cellulaire en rĂ©ponse Ă  l’association cetuximab-pertuzumab combinĂ©e Ă  l’irradiation photonique. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01277945⟩
  • D. Ardail, M. Gilormini, C. Maleysis, C. Rodriguez-Lafrasse. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on Head and Neck Squamous Cell Carcinoma. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01277897⟩
  • Floriane Poignant. ModĂ©lisation biophysique des effets radiosensibilisants des nanoparticules. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01297474⟩
  • Anne-Sophie Wozny, Alexandra Lauret, Yannick Saintigny, Priscillia Battiston-Montagne, MichaĂ«l Beuve, et al.. Essential role of HIF-1α in both resistance to photon and carbon ion exposures and invasiveness of Head and Neck Squamous Cell Carcinoma (HNSCC) cancer stem cells. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01277916⟩
  • ValĂ©rian Reithinger. Assurance qualitĂ© des traitements par hadronthĂ©rapie carbone par imagerie de particules promptes chargĂ©es. JournĂ©e de la Recherche 2016, FacultĂ© de MĂ©decine Lyon-Est, Mar 2016, Lyon, France. ⟨hal-01438834⟩
  • Shady Kotb, François Lux, Claire Rodriguez-Lafrasse, Olivier Tillement, Lucie Sancey. Nanoparticle Enhanced MRI-Guided Radiation Therapy: Final proof of concept before phase I trial.. ICTR-PHE 2016, Feb 2016, Genève, Switzerland. ⟨hal-01275090⟩
  • B. Huisman, Jean Michel LĂ©tang, E. Testa, D. Sarrut. Accelerated Prompt Gamma estimation for clinical Proton Therapy simulations. International Conference on Translational Research in Radio-Oncology | Physics for Health in Europe (ICTR-PHE 2016), Feb 2016, Genève, Switzerland. . ⟨hal-01276369⟩

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