Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
393 documents

  • P. Gueth, D. Dauvergne, N. Freud, J.-M. Létang, C. Ray, et al.. Machine-learning-based patient specific prompt-gamma dose monitoring in protontherapy. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838405⟩
  • W. Enghardt, D. Dauvergne, J. Barrio, C. Cabello, J. Gillam, et al.. Monitoring the Bragg peak during ion therapy by means of prompt radiation. The ENVISION program. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838430⟩
  • V. Reithinger, J. Baudot, S. Brons, D. Dauvergne, G. Dedes, et al.. Proton Interaction Vertex Imaging With Silicon-Pixel CMOS Telescope For Carbon Therapy Quality Control. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838442⟩
  • S. Rit, G. Dedes, N. Freud, D. Sarrut, J.-M. Letang. Filtered backprojection proton CT reconstruction along most likely paths. Medical Physics : The international journal of medical physics research and practice, 2013, 40 (3), pp.031103. ⟨10.1118/1.4789589⟩. ⟨hal-00796949⟩
  • L. Chollier. Modélisation biophysique de l'interaction des ions de hautes énergies avec la matière vivante : application aux traitements de tumeurs par hadronthérapie. 2012. ⟨hal-00949681⟩
  • Marie-Hélène Richard. Design study of a Compton camera for prompts-gamma imaging during ion beam therapy. Other [cond-mat.other]. Université Claude Bernard - Lyon I, 2012. English. ⟨NNT : 2012LYO10124⟩. ⟨tel-00934715⟩
  • Jacques Saadé, Hamid Ladjal, Shariat Behzad, M. Beuve, Joseph Azencot. Modélisation biomécanique du diaphragme humain : du CT-4D au modèle du mouvement. RFIA 2012 (Reconnaissance des Formes et Intelligence Artificielle), Jan 2012, Lyon, France. pp.978-2-9539515-2-3. ⟨hal-00656533⟩
  • M. Beuve. Methods for Radiobiological Data Acquisition, Processing, Analysis and Modelling. 1st International Workshop: Hadrontherapy in France, Nov 2011, Lyon, France. ⟨in2p3-00773078⟩
  • M. Beuve, M.-A. Chanrion, U. Jelen, A. Wittig, K. Zink, et al.. The Need of Clinical Endpoint to feed RBE Models. 2nd NIRS-ETOILE Joint Symposium on Carbon Ion Therapy, Nov 2011, Lyon, France. ⟨in2p3-00773048⟩
  • M. Beuve. O2 and glutathione effects on water radiolysis: a simulation study. Nano-IBCT (Nano-scale insights into Ion Beam Cancer Therapy) 2011: Radiation damage of biomolecular systems, Oct 2011, Caen, France. ⟨in2p3-00772876⟩

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