Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Deng, H. Mathez, D. Dauvergne, Y. Zoccarato, G.-N. Lu. Front-end multi-channel PMT-associated readout chip for hodoscope application. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2012, 695, pp.390-393. ⟨10.1016/j.nima.2011.11.042⟩. ⟨hal-00990855⟩
  • N. Toulhoat, N. Moncoffre, Y. Pipon, N. BĂ©rerd, G. Silbermann, et al.. Synergisitic of decoupled effects of temperature and irradiation on ^{14}C and ^{36}Cl behavior in irradiated graphite studied through ion implantation or irradiation of virgin nuclear graphite. Irradiation damage and formation in Nuclear Graphite Joint Meeting in conjunction with the FP7 Carbowaste program, Nov 2012, Manchester, United Kingdom. ⟨in2p3-00981346⟩
  • T. Feldmann, A. Bauch, D. Piester, P. Alvarez, D. Autiero, et al.. Relative Calibration of the Time Transfer Link Between CERN and LNGS for Precise Neutrino Time of Flight Measurements. 44th Annual Precise Time and Time Interval Systems and Applications Meeting, Nov 2012, Reston, United States. ⟨in2p3-01019279⟩
  • Laurence LunĂ©ville, Ludovic Largeau, Cyrile Deranlot, Nathalie Moncoffre, Yves Serruys, et al.. Nanostructuration of Cr/Si Layers Induced by Ion Beam Mixing. Symposium HH – Advances in Materials for Nuclear Energy, Nov 2012, Boston, United States. ⟨hal-00761651⟩
  • Laurence LunĂ©ville, Ludovic Largeau, Cyrile Deranlot, Nathalie Moncoffre, Yves Serruys, et al.. Nanostructuration of cr/si layers induced by ion beam mixing.. Symposium HH – Advances in Materials for Nuclear Energy, Nov 2012, Boston, France. pp.61-68, ⟨10.1557/opl.2013.196⟩. ⟨hal-00913647⟩
  • Dominique Gorse-Pomonti, Ngoc-Long Do, Nicolas Bererd, Nathalie Moncoffre, Gianguido Baldinozzi. Titanium and zirconium oxidation under argon irradiation in the low MeV range. Symposium HH – Advances in Materials for Nuclear Energy, Nov 2012, Boston, United States. pp.81-85, ⟨10.1557/opl.2013.127⟩. ⟨hal-00818067⟩
  • G. Cacciapaglia. All other Scenarios. UK HEP Forum "Higgs & BSM", Nov 2012, Abingdon, United Kingdom. ⟨in2p3-01025062⟩
  • S. Pirrone, G. Politi, M. La Commara, J.P. Wieleczko, G. Ademard, et al.. Influence of neutron enrichment on compound system formation and decay in 78Kr+40Ca and 86Kr+48Ca reactions at 10 AMeV. International Conference on Recent Trends in Nuclear Physics, Nov 2012, Barotiwala, India. pp.7-10, ⟨10.1063/1.4801667⟩. ⟨in2p3-00807742⟩
  • S. Gascon-Shotkin. H to gamma-gamma at LHC. Higgs Coupling 2012 Workshop (HC2012), Nov 2012, Tokyo, Japan. ⟨in2p3-00967843⟩
  • K. Abe, D. Autiero, O. Drapier, J. Dumarchez, G. Giganti, et al.. Recent Results from the T2K Experiment. 9th International Symposium on Cosmology and Particle Astrophysics, Nov 2012, Taipei & Hsinchu, Japan. pp.23-28, ⟨10.1016/j.nuclphysbps.2013.10.060⟩. ⟨in2p3-00976883⟩

Powered by HAL logo