Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Forward-backward asymmetry of Drell-Yan lepton pairs in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2013, 718, pp.752-772. ⟨10.1016/j.physletb.2012.10.082⟩. ⟨in2p3-00718706⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Measurement of differential top-quark pair production cross sections in pp colisions at sqrt(s) = 7 TeV. European Physical Journal C: Particles and Fields, 2013, 73, pp.2339. ⟨10.1140/epjc/s10052-013-2339-4⟩. ⟨in2p3-00750661⟩
  • Isabelle Billard, Ali Ouadi, Clotilde Gaillard. Is a universal model to describe liquid/liquid extraction of cations by use of ionic liquids at reach?. Dalton Transactions, 2013, 42 (17), pp.6203-6212. ⟨10.1039/C3DT32159B⟩. ⟨hal-02271584⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Measurement of the W^+W^- cross section in pp collisions at \sqrt{s} = 7 TeV and limits on anomalous WW\gamma and WWZ couplings. European Physical Journal C: Particles and Fields, 2013, 73, pp.2610. ⟨10.1140/epjc/s10052-013-2610-8⟩. ⟨in2p3-00830891⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for heavy quarks decaying into a top quark and a W or Z boson using lepton + jets events in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2013, 1, pp.154. ⟨10.1007/JHEP01(2013)154⟩. ⟨in2p3-00746900⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. The performance of the CMS muon detector in proton-proton collisions at sqrt(s) = 7 TeV at the LHC. Journal of Instrumentation, 2013, 8, pp.P11002. ⟨10.1088/1748-0221/8/11/P11002⟩. ⟨in2p3-00839855⟩
  • V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Search for charged massive long-lived particles at sqrt(s)= 1.96 TeV. Physical Review D, 2013, 87, pp.052011. ⟨10.1103/PhysRevD.87.052011⟩. ⟨in2p3-00751223⟩
  • V.M. Abazov, F. Badaud, U. Bassler, M. Besançon, D. Brown, et al.. Measurement of the muon charge asymmetry in ppbar to W + X to mu nu + X events at sqrt{s} = 1.96 TeV. Physical Review D, 2013, 88, pp.091102(R). ⟨10.1103/PhysRevD.88.091102⟩. ⟨in2p3-00860904⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Measurement of the X(3872) production cross section via decays to J/psi pi pi in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2013, 04(2013), pp.154. ⟨10.1007/JHEP04(2013)154⟩. ⟨in2p3-00789895⟩
  • V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Measurement of the combined rapidity and p_T dependence of dijet azimuthal decorrelations in p\bar{p} collisions at \sqrt{s}=1.96\,TeV. Physics Letters B, 2013, 721, pp.212-219. ⟨10.1016/j.physletb.2013.03.029⟩. ⟨in2p3-00763503⟩

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