Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- M. Buchkremer, G. Cacciapaglia, A. Deandrea, L. Panizzi. Model-independent framework for searches of top partners. Nuclear Physics B - Proceedings Supplements, 2013, 876, pp.376-417. ⟨10.1016/j.nuclphysb.2013.08.010⟩. ⟨in2p3-00826381⟩
- T. Mizutani, C. Fayard, B. Saghai, K. Tsushima. Faddeev-Chiral Unitary Approach to the
scattering length. Physical Review C, 2013, 87, pp.035201. ⟨10.1103/PhysRevC.87.035201⟩. ⟨in2p3-00871678⟩ - G. Cacciapaglia. Presentation at Workshop Origin of the Mass 2013. Workshop Origin of the Mass 2013, 2013, Odense, Denmark. ⟨in2p3-01025125⟩
- J. Sadoudi, T. Duguet, J. Meyer, M. Bender. Skyrme functional from a three-body pseudopotential of second order in gradients: Formalism for central terms. Physical Review C, 2013, 88, pp.064326. ⟨10.1103/PhysRevC.88.064326⟩. ⟨in2p3-00941934⟩
- L. Rinolfi, R. Chehab, O. Dadoun, T. Kamitani, V. Strakhovenko, et al.. Brilliant positron sources for CLIC and other collider projects. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2013, 309, pp.50-55. ⟨10.1016/j.nimb.2013.01.027⟩. ⟨in2p3-00788579⟩
- C. Alexa, J.C. Bizot, V. Brisson, B. Delcourt, M. Jacquet, et al.. Elastic and Proton-Dissociative Photoproduction of J/psi Mesons at HERA. European Physical Journal C: Particles and Fields, 2013, 73, pp.2466. ⟨10.1140/epjc/s10052-013-2466-y⟩. ⟨in2p3-00816384⟩
- H. Abramowicz, J.C. Bizot, V. Brisson, B. Delcourt, M. Jacquet, et al.. Combination and QCD Analysis of Charm Production Cross Section Measurements in Deep-Inelastic ep Scattering at HERA. European Physical Journal C: Particles and Fields, 2013, 73, pp.2311. ⟨10.1140/epjc/s10052-013-2311-3⟩. ⟨in2p3-00749294⟩
- S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Interpretation of searches for supersymmetry with simplified models. Physical Review D, 2013, 88, pp.052017. ⟨10.1103/PhysRevD.88.052017⟩. ⟨in2p3-00772852⟩
- V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Combined search for the Higgs boson with the D0 experiment. Physical Review D, 2013, 88, pp.052011. ⟨10.1103/PhysRevD.88.052011⟩. ⟨in2p3-00796748⟩
- S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Measurement of the Lambda(b)0 lifetime in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2013, 07(2013), pp.163. ⟨10.1007/JHEP07(2013)163⟩. ⟨in2p3-00819067⟩
Powered by HAL 