The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- B. Abelev, N. Arbor, G. Conesa Balbastre, J. Faivre, C. Furget, et al.. Charge correlations using the balance function in Pb-Pb collisions at sqrt{s_{NN}} = 2.76 TeV. Physics Letters B, 2013, 723, pp.267-279. ⟨10.1016/j.physletb.2013.05.039⟩. ⟨in2p3-00777176⟩
- E. Abbas, N. Arbor, G. Conesa Balbastre, J. Faivre, C. Furget, et al.. Mid-rapidity anti-baryon to baryon ratios in pp collisions at sqrt(s) = 0.9, 2.76 and 7 TeV measured by ALICE. European Physical Journal C: Particles and Fields, 2013, 73, pp.2496. ⟨10.1140/epjc/s10052-013-2496-5⟩. ⟨in2p3-00821780⟩
- G. Grenier. Construction and commissioning of the SDHCAL technological prototype. Calorimetry for High Energy Frontiers - CHEF 2013, 2013, Paris, France. ⟨in2p3-00862328⟩
- T. Mizutani, C. Fayard, B. Saghai, K. Tsushima. Faddeev-Chiral Unitary Approach to the
scattering length. Physical Review C, 2013, 87, pp.035201. ⟨10.1103/PhysRevC.87.035201⟩. ⟨in2p3-00871678⟩
- R. Brent Tully, H.M. Courtois, A.E. Dolphin, J.R. Fisher, P. Heraudeau, et al.. Cosmicflows-2: The Data. The Astronomical Journal, 2013, 146, pp.146. ⟨10.1088/0004-6256/146/4/86⟩. ⟨in2p3-00857363⟩
- C. Alexa, J.C. Bizot, V. Brisson, B. Delcourt, M. Jacquet, et al.. Elastic and Proton-Dissociative Photoproduction of J/psi Mesons at HERA. European Physical Journal C: Particles and Fields, 2013, 73, pp.2466. ⟨10.1140/epjc/s10052-013-2466-y⟩. ⟨in2p3-00816384⟩
- H. Abramowicz, J.C. Bizot, V. Brisson, B. Delcourt, M. Jacquet, et al.. Combination and QCD Analysis of Charm Production Cross Section Measurements in Deep-Inelastic ep Scattering at HERA. European Physical Journal C: Particles and Fields, 2013, 73, pp.2311. ⟨10.1140/epjc/s10052-013-2311-3⟩. ⟨in2p3-00749294⟩
- A. Abdalgabar, As. Cornell, A. Deandrea, A. Tarhini. Higgs quartic coupling and neutrino sector evolution in 2UED models. European Physical Journal C: Particles and Fields, 2013, 74, pp.2893. ⟨10.1140/epjc/s10052-014-2893-4⟩. ⟨in2p3-00848087⟩
- A. S. Cornell, A. Deandrea, Lu-Xin Liu, A. Tarhini. The evolution of neutrino masses and mixings in the 5D MSSM. The European Physical Journal Plus, 2013, 128, pp.6. ⟨10.1140/epjp/i2013-13006-4⟩. ⟨in2p3-00722268⟩
- S. Béné, Pierre Boivin, Emmanuel Busato, C. Cârloganu, C. Combaret, et al.. Air shower simulation for background estimation in muon tomography of volcanoes. Geoscientific Instrumentation, Methods and Data Systems, 2013, 2, pp.11-15. ⟨10.5194/gi-2-11-2013⟩. ⟨hal-00811452⟩