Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for a light pseudoscalar Higgs boson in the boosted \mu\mu\tau\tau final state in proton-proton collisions at \sqrt{s}= 13 TeV. JHEP, 2020, 08, pp.139. ⟨10.1007/JHEP08(2020)139⟩. ⟨hal-02739683⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of the top quark pair production cross section in dilepton final states containing one \tau lepton in pp collisions at \sqrt{s}= 13 TeV. JHEP, 2020, 02, pp.191. ⟨10.1007/JHEP02(2020)191⟩. ⟨hal-02416918⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Dependence of inclusive jet production on the anti-k_{T} distance parameter in pp collisions at \sqrt{\mathrm{s}} = 13 TeV. JHEP, 2020, 12, pp.082. ⟨10.1007/JHEP12(2020)082⟩. ⟨hal-02628119⟩
    • Aurelien Carle, Nicolas Chanon, Stephane Perries. Prospects for Lorentz Invariance Violation searches with top pair production at the LHC and future hadron colliders. European Physical Journal C: Particles and Fields, 2020, 80 (2), pp.128. ⟨10.1140/epjc/s10052-020-7715-2⟩. ⟨hal-02309061⟩
    • Peng Wang, Xi Kang, Noam I. Libeskind, Quan Guo, Stefan Gottlöber, et al.. A robust determination of halo environment in the cosmic field. New Astron., 2020, 80, pp.101405. ⟨10.1016/j.newast.2020.101405⟩. ⟨hal-02870813⟩
    • Luis F. Quiroga, J.C. Muñoz-Cuartas, I. Rodrigues, Noam I. Libeskind. Simulating the galactic system in interaction AM 2229-735 and the formation of its polar structure. Monthly Notices of the Royal Astronomical Society, 2020, 491 (2), pp.1887-1900. ⟨10.1093/mnras/stz2943⟩. ⟨hal-02447938⟩
    • Caterina Monini, Micaela Cunha, Laurie Chollier, Etienne Testa, Michael Beuve. Determination of the Effective Local Lethal Function for the NanOx Model. Rad.Res., 2020, 193 (4), pp.331-340. ⟨10.1667/rr15463.1⟩. ⟨hal-02571523⟩
    • Chen-Hui Chan, Floriane Poignant, Michael Beuve, Elise Dumont, David Loffreda. Effect of the Ligand Binding Strength on the Morphology of Functionalized Gold Nanoparticles. Journal of Physical Chemistry Letters, 2020, pp.2717-2723. ⟨10.1021/acs.jpclett.0c00300⟩. ⟨hal-02519412⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Measurements of inclusive jet spectra in pp and central Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 5.02 TeV. Phys.Rev.C, 2020, 101 (3), pp.034911. ⟨10.1103/PhysRevC.101.034911⟩. ⟨hal-02327851⟩
    • K. Yamakawa, A. Augustinus, Guillaume Batigne, P. Chochula, M. Oya, et al.. Design and Implementation of Detector Control System for Muon Forward Tracker at ALICE. Journal of Instrumentation, 2020, 15 (10), pp.T10002. ⟨10.1088/1748-0221/15/10/T10002⟩. ⟨hal-02899258⟩

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