Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Y. Uesugi, T. Akagi, R. Chehab, O. Dadoun, K. Furukawa, et al.. Development of an intense positron source using a crystal--amorphous hybrid target for linear colliders. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2013, 319, pp.17-23. ⟨10.1016/j.nimb.2013.10.025⟩. ⟨in2p3-00914266⟩
  • A. Arbey, M. Battaglia, A. Djouadi, F. Mahmoudi. An update on the constraints on the phenomenological MSSM from the new LHC Higgs results. Physics Letters B, 2013, 720, pp.153-160. ⟨10.1016/j.physletb.2013.02.001⟩. ⟨in2p3-00753289⟩
  • M. Buchkremer, G. Cacciapaglia, A. Deandrea, L. Panizzi. Model-independent framework for searches of top partners. Nuclear Physics B - Proceedings Supplements, 2013, 876, pp.376-417. ⟨10.1016/j.nuclphysb.2013.08.010⟩. ⟨in2p3-00826381⟩
  • M. J. Childress, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. Host Galaxy Properties and Hubble Residuals of Type Ia Supernovae from the Nearby Supernova Factory. The Astrophysical Journal, 2013, 770, pp.108. ⟨10.1088/0004-637X/770/2/108⟩. ⟨in2p3-00826354⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Measurement of W+W- and ZZ production cross sections in pp collisions at sqrt(s)=8 TeV. Physics Letters B, 2013, 720, pp.190-211. ⟨10.1016/j.physletb.2013.03.027⟩. ⟨in2p3-00779294⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Measurement of the t t-bar production cross section in pp collisions at sqrt(s) = 7 TeV with lepton + jets final states. Physics Letters B, 2013, 720, pp.83-104. ⟨10.1016/j.physletb.2013.02.021⟩. ⟨in2p3-00865303⟩
  • S. Chatrchyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the prompt J/psi and psi(2S) polarizations in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2013, 727, pp.381-402. ⟨10.1016/j.physletb.2013.10.055⟩. ⟨in2p3-00847615⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Studies of jet quenching using isolated-photon+jet correlations in PbPb and pp collisions at sqrt(s[NN]) = 2.76 TeV. Physics Letters B, 2013, 718, pp.773-794. ⟨10.1016/j.physletb.2012.11.003⟩. ⟨in2p3-00694331⟩
  • S. Chatrchyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Multiplicity and transverse-momentum dependence of two- and four-particle correlations in pPb and PbPb collisions. Physics Letters B, 2013, 724, pp.213-240. ⟨10.1016/j.physletb.2013.06.028⟩. ⟨in2p3-00820574⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Searches for long-lived charged particles in pp collisions at sqrt(s)=7 and 8 TeV. Journal of High Energy Physics, 2013, 07(2013), pp.122. ⟨10.1007/JHEP07(2013)122⟩. ⟨in2p3-00820057⟩

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