Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • C. Buton, Y. Copin, G. Aldering, P. Antilogus, C. Aragon, et al.. Atmospheric extinction properties above Mauna Kea from the Nearby Supernova Factory spectro-photometric data set. Astronomy & Astrophysics - A&A, 2013, 549, pp.A8. ⟨10.1051/0004-6361/201219834⟩. ⟨in2p3-00740358⟩
  • V. Vandone, S. Leoni, G. Benzoni, N. Blasi, A. Bracco, et al.. Global properties of K hindrance probed by the gamma decay of the warm rotating W-174 nucleus. Physical Review C, 2013, 88, pp.034312. ⟨10.1103/PhysRevC.88.034312⟩. ⟨in2p3-00916808⟩
  • E. Abbas, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, A.A.E. Bergognon, et al.. J/Psi Elliptic Flow in Pb-Pb Collisions at sqrt(sNN) = 2.76 TeV. Physical Review Letters, 2013, 111, pp.162301. ⟨10.1103/PhysRevLett.111.162301⟩. ⟨in2p3-00804625⟩
  • J. Sorce, H.M. Courtois, R. B. Tully, Mark Seibert, V. Scowcroft, et al.. Calibration of the Mid-Infrared Tully-Fisher Relation. The Astrophysical Journal, 2013, 765, pp.95. ⟨10.1088/0004-637X/765/2/94⟩. ⟨in2p3-00788203⟩
  • A. S. Cornell, A. Deandrea, Lu-Xin Liu, A. Tarhini. Renormalisation running of masses and mixings in UED models. Modern Physics Letters A, 2013, 28, pp.1330007. ⟨10.1142/S0217732313300073⟩. ⟨in2p3-00747518⟩
  • S. Deng, D. Dauvergne, G.-N. Lu, H. Mathez, Y. Zoccarato. Very fast front end ASIC associated with multi-anode PMTs for a scintillating-fibre beam hodoscope. Journal of Instrumentation, 2013, 8, pp.C01047. ⟨10.1088/1748-0221/8/01/C01047⟩. ⟨hal-00990850⟩
  • T. Doumler, H.M. Courtois, S. Gottloeber, Y. Hoffman. Reconstructing cosmological initial conditions from galaxy peculiar velocities. II. The effect of observational errors. Monthly Notices of the Royal Astronomical Society, 2013, 430, pp.902-911. ⟨10.1093/mnras/sts603⟩. ⟨in2p3-00788205⟩
  • J. Sorce, H.M. Courtois, K. Sheth, R. Brent Tully. Bimodality of Galaxy Disk Central Surface Brightness Distribution in the Spitzer 3.6 micron band. Monthly Notices of the Royal Astronomical Society, 2013, 433, pp.751-758. ⟨10.1093/mnras/stt768⟩. ⟨in2p3-00826379⟩
  • B. Abelev, C. Cheshkov, B. Cheynis, L. Ducroux, J.-Y. Grossiord, et al.. Measurement of inelastic, single- and double-diffraction cross sections in proton--proton collisions at the LHC with ALICE. European Physical Journal C: Particles and Fields, 2013, 73, pp.2456. ⟨10.1140/epjc/s10052-013-2456-0⟩. ⟨in2p3-00725471⟩
  • Thibaut Capron, Guillaume Forestier, Angela Perrat-Mabilon, Christophe Peaucelle, Tristan Meunier, et al.. Magnetic dephasing in mesoscopic spin glasses. Physical Review Letters, 2013, 111, pp.187203. ⟨10.1103/PhysRevLett.111.187203⟩. ⟨ensl-00806023⟩

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