Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- Dominique Gibert, Karine Marteau-Bazouni, Jacques Marteau. Radiographier les volcans avec les rayons cosmiques. Reflets de la Physique, 2013, 32, pp.14-18. ⟨10.1051/refdp/201332014⟩. ⟨insu-00958307⟩
- M. Bicer, H. Duran Yildiz, I. Yildiz, G. Coignet, M. Delmastro, et al.. First Look at the Physics Case of TLEP. Journal of High Energy Physics, 2013, 01, pp.164. ⟨10.1007/JHEP01(2014)164⟩. ⟨in2p3-00956389⟩
- H. Samtleben, E. Sezgin, D. Tsimpis. Rigid 6D supersymmetry and localization. Journal of High Energy Physics, 2013, 1303, pp.137. ⟨10.1007/JHEP03(2013)137⟩. ⟨in2p3-00767571⟩
- S. Chiacchiera, D. Davesne, T. Enss, Michael Urban. Damping of the quadrupole mode in a two-dimensional Fermi gas: an unsolved puzzle. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 2013, 88, pp.053616. ⟨10.1103/PhysRevA.88.053616⟩. ⟨in2p3-00867546⟩
- V. Hellemans, A. Pastore, T. Duguet, K. Bennaceur, D. Davesne, et al.. Spurious finite-size instabilities in nuclear energy density functionals. Physical Review C, 2013, 88, pp.064323. ⟨10.1103/PhysRevC.88.064323⟩. ⟨in2p3-00904257⟩
- U. Feindt, M. Kerschhaggl, M. Kowalski, G. Aldering, P. Antilogus, et al.. Measuring cosmic bulk flows with Type Ia Supernovae from the Nearby Supernova Factory. Astronomy & Astrophysics - A&A, 2013, 560, pp.A90. ⟨10.1051/0004-6361/201321880⟩. ⟨in2p3-00904274⟩
- S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for a Higgs boson decaying into a b-quark pair and produced in association with b quarks in proton-proton collisions at 7 TeV. Physics Letters B, 2013, 722, pp.207-232. ⟨10.1016/j.physletb.2013.04.017⟩. ⟨in2p3-00787800⟩
- V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Measurement of the ppbar -> W+b+X production cross section at \sqrt{s}=1.96 TeV. Physics Letters B, 2013, 718, pp.1314-1320. ⟨10.1016/j.physletb.2012.12.044⟩. ⟨in2p3-00737940⟩
- N. Agafonova, Alexander Aleksandrov, A. Anokhina, S. Aoki, A. Ariga, et al.. Search for
oscillations with the OPERA experiment in the CNGS beam. Journal of High Energy Physics, 2013, 07(2013), pp.004. ⟨10.1007/JHEP07(2013)004⟩. ⟨in2p3-00802085⟩ - S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Observation of a diffractive contribution to dijet production in proton-proton collisions at sqrt(s)=7 TeV. Physical Review D, 2013, 87, pp.012006. ⟨10.1103/PhysRevD.87.012006⟩. ⟨in2p3-00730778⟩
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