Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for new physics in events with same-sign dileptons and b jets in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2013, 03(2013), pp.037. ⟨10.1007/JHEP03(2013)037⟩. ⟨in2p3-00848805⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Search for Z' resonances decaying to ttbar in dilepton+jets final states in pp collisions at sqrt(s) = 7 TeV. Physical Review D, 2013, 87, pp.072002. ⟨10.1103/PhysRevD.87.072002⟩. ⟨in2p3-00752167⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for supersymmetry in events with opposite-sign dileptons and missing transverse energy using an artificial neural network. Physical Review D, 2013, 87, pp.072001. ⟨10.1103/PhysRevD.87.072001⟩. ⟨in2p3-00771015⟩
  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for supersymmetry in pp collisions at sqrt(s) = 7 TeV in events with a single lepton, jets, and missing transverse momentum. European Physical Journal C: Particles and Fields, 2013, 73, pp.2404. ⟨10.1140/epjc/s10052-013-2404-z⟩. ⟨in2p3-00865284⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for supersymmetry in final states with missing transverse energy and 0, 1, 2, or at least 3 b-quark jets in 7 TeV pp collisions using the variable alphaT. Journal of High Energy Physics, 2013, 1, pp.077. ⟨10.1007/JHEP01(2013)077⟩. ⟨in2p3-00747312⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Search for the standard model Higgs boson produced in association with a top-quark pair in pp collisions at the LHC. Journal of High Energy Physics, 2013, 05(2013), pp.145. ⟨10.1007/JHEP05(2013)145⟩. ⟨in2p3-00796746⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Measurement of the ratio of the inclusive 3-jet cross section to the inclusive 2-jet cross section in pp collisions at sqrt(s) = 7 TeV and first determination of the strong coupling constant in the TeV range. European Physical Journal C: Particles and Fields, 2013, 73, pp.2604. ⟨10.1140/epjc/s10052-013-2604-6⟩. ⟨in2p3-00819068⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Observation of a new boson with mass near 125 GeV in pp collisions at sqrt(s) = 7 and 8 TeV. Journal of High Energy Physics, 2013, 06(2013), pp.081. ⟨10.1007/JHEP06(2013)081⟩. ⟨in2p3-00802503⟩
  • A. Abdalgabar, A.S. Cornell, A. Deandrea, A. Tarhini. Evolution of Yukawa couplings and quark flavour mixings in 2UED models. Physical Review D, 2013, 88, pp.056006. ⟨10.1103/PhysRevD.88.056006⟩. ⟨in2p3-00869843⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Search for top squarks in R-parity-violating supersymmetry using three or more leptons and b-tagged jets. Physical Review Letters, 2013, 111, pp.221801. ⟨10.1103/PhysRevLett.111.221801⟩. ⟨in2p3-00839854⟩

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