Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Abelev, Laurent Aphecetche, A. Baldisseri, I. Belikov, A.A.E. Bergognon, et al.. Measurement of the inclusive differential jet cross section in pp collisions at sqrt{s} = 2.76 TeV. Physics Letters B, 2013, 722, pp.262-272. ⟨10.1016/j.physletb.2013.04.026⟩. ⟨in2p3-00776989⟩
  • B. Abelev, Laurent Aphecetche, Y.W. Baek, A. Baldisseri, V. Barret, et al.. Multiplicity dependence of the average transverse momentum in pp, p-Pb, and Pb-Pb collisions at the LHC. Physics Letters B, 2013, 727, pp.371-380. ⟨10.1016/j.physletb.2013.10.054⟩. ⟨in2p3-00841162⟩
  • Leila Sadr Arani, Pierre Mignon, H. Abdoul-Carime, B. Farizon, M. Farizon, et al.. Hydrogen release from charged fragments of the uracil cation followed by their fragmentation: A DFT study. Chemical Physics Letters, 2013, 583, pp.165-169. ⟨10.1016/j.cplett.2013.07.082⟩. ⟨in2p3-00871668⟩
  • K. Abe, D. Autiero, J. P. A. M. de Andre, O. Drapier, J. Dumarchez, et al.. Measurement of the Inclusive NuMu Charged Current Cross Section on Carbon in the Near Detector of the T2K Experiment. Physical Review D, 2013, 87, pp.092003. ⟨10.1103/PhysRevD.87.092003⟩. ⟨in2p3-00839171⟩
  • Hanindyo Kuncarayakti, Mamoru Doi, Greg Aldering, Nobuo Arimoto, Keiichi Maeda, et al.. Integral field spectroscopy of supernova explosion sites: constraining mass and metallicity of the progenitors -- II. Type II-P and II-L supernovae. The Astronomical Journal, 2013, 146, pp.31. ⟨10.1088/0004-6256/146/2/31⟩. ⟨in2p3-00859692⟩
  • T. Arriga, P. Nédélec, L. Cabaret, D. Comparat. Measuring GBAR with emulsion detector. 2nd International Workshop on Antimatter and Gravity (WAG 2013), 2013, Bern, Switzerland. pp.1460268, ⟨10.1142/S2010194514602683⟩. ⟨in2p3-01006671⟩
  • G. Cacciapaglia. Presentation at Rencontres de Physique des Particules 2013. Rencontres de Physique des Particules 2013, 2013, Grenoble, France. ⟨in2p3-01025122⟩
  • N. Abgrall, D. Autiero, F.D.M. Blaszczyk, J.P.A.M. de Andre, O. Drapier, et al.. Evidence of Electron Neutrino Appearance in a Muon Neutrino Beam. Physical Review D, 2013, 88, pp.032002. ⟨10.1103/PhysRevD.88.032002⟩. ⟨in2p3-00807576⟩
  • A. Astier, M. -G. Porquet, Ts. Venkova, G. Duchene, F. Azaiez, et al.. High-spin structures of ^{88}_{36}Kr_{52} and ^{89}_{37}Rb_{52}: Evolution from collective to single-particle behavior. Physical Review C, 2013, 88, pp.024321. ⟨10.1103/PhysRevC.88.024321⟩. ⟨in2p3-00857354⟩
  • M. Gouzevitch, A. Oliveira, J. Rojo, R. Rosenfeld, G. Salam, et al.. Scale-invariant resonance tagging in multijet events and new physics in Higgs pair production. Journal of High Energy Physics, 2013, 07(2013), pp.148. ⟨10.1007/JHEP07(2013)148⟩. ⟨in2p3-00805469⟩

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