Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Chatrchyan, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for fractionally charged particles in pp collisions at sqrt(s) = 7 TeV. Physical Review D, 2013, 87, pp.092008. ⟨10.1103/PhysRevD.87.092008⟩. ⟨in2p3-00739798⟩
  • V.M. Abazov, F. Badaud, U. Bassler, G. Bernardi, M. Besançon, et al.. Measurement of the Asymmetry in Angular Distributions of Leptons Produced in Dilepton t\overline{t} Final States in p\overline{p} Collisions at \sqrt{s}=1.96 TeV. Physical Review D, 2013, 88, pp.112002. ⟨10.1103/PhysRevD.88.112002⟩. ⟨in2p3-00856609⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, M. Dejardin, D. Denegri, et al.. Search for supersymmetry in final states with a single lepton, b-quark jets, and missing transverse energy in proton-proton collisions at sqrt(s) = 7 TeV. Physical Review D, 2013, 87, pp.052006. ⟨10.1103/PhysRevD.87.052006⟩. ⟨in2p3-00752166⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Measurement of the hadronic activity in events with a Z and two jets and extraction of the cross section for the electroweak production of a Z with two jets in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2013, 2013(10), pp.062. ⟨10.1007/JHEP10(2013)062⟩. ⟨in2p3-00829244⟩
  • V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Search for Higgs boson production in oppositely charged dilepton and missing energy final states in 9.7 fb-1 of ppbar collisions at sqrts = 1.96 TeV. Physical Review D, 2013, 88, pp.052006. ⟨10.1103/PhysRevD.88.052006⟩. ⟨in2p3-00771017⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Search for new physics in final states with a lepton and missing transverse energy in pp collisions at the LHC. Physical Review D, 2013, 87, pp.072005. ⟨10.1103/PhysRevD.87.072005⟩. ⟨in2p3-00787799⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Search for supersymmetry in hadronic final states with missing transverse energy using the variables AlphaT and b-quark multiplicity in pp collisions at 8 TeV. European Physical Journal C: Particles and Fields, 2013, 73, pp.2568. ⟨10.1140/epjc/s10052-013-2568-6⟩. ⟨in2p3-00799961⟩
  • S. Chatrchyan, M. Besançon, S. Choudhury, F. Couderc, M. Dejardin, et al.. Search for narrow resonances using the dijet mass spectrum in pp collisions at sqrt(s) = 8 TeV. Physical Review D, 2013, 87, pp.114015. ⟨10.1103/PhysRevD.87.114015⟩. ⟨in2p3-00790738⟩
  • Angélie Portal, Philippe Labazuy, Jean-François Lénat, S. Béné, Pierre Boivin, et al.. Inner structure of the Puy de Dˆome volcano: cross-comparison of geophysical models (ERT, gravimetry, muon imaging). Geoscientific Instrumentation, Methods and Data Systems, 2013, 2, pp.47-54. ⟨10.5194/gi-2-47-2013⟩. ⟨hal-00811456⟩
  • Clémentine Aguirre, Tim Ten Brink, Olivier Walker, Florence Guillière, D. Davesne, et al.. BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR. PLoS ONE, 2013, 8, pp.e64400. ⟨10.1371/journal.pone.0064400⟩. ⟨in2p3-00839023⟩

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