Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Uras. Physique des muons dans ALICE : morceaux choisis de l'analyse actuelle et perspectives futures. Séminaire au LLR, Mar 2013, Palaiseau, France. ⟨in2p3-01019718⟩
  • A. Uras. Physique des muons dans ALICE : morceaux choisis de l'analyse actuelle et perspectives futures. Séminaire à SUBATECH, Mar 2013, Nantes, France. ⟨in2p3-01019717⟩
  • M. Gouzevitch. Problématiques expérimentales et théoriques. Séminaire, Mar 2013, Saclay, France. ⟨in2p3-00972030⟩
  • A. Uras. Physique des muons dans ALICE : morceaux choisis de l'analyse actuelle et perspectives futures. Séminaire au LPSC, Mar 2013, Grenoble, France. ⟨in2p3-01019713⟩
  • J. Dudouet, M. Labalme, J.C. Angélique, J. Colin, D. Cussol, et al.. Nuclear Fragmentation Measurements for Hadrontherapy: 95MeV/u 12C Reactions on H, C, Al, O and natTi Targets. International Conference on Nuclear Data for Science and Technology (ND2013), Mar 2013, New York, United States. ⟨in2p3-00797002⟩
  • G. Alphonse, M. Maalouf, P. Battiston-Montagne, D. Ardail, M. Beuve, et al.. p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation. BMC Cancer, 2013, 13, pp.151. ⟨10.1186/1471-2407-13-151⟩. ⟨hal-00850652⟩
  • S. Rit, G. Dedes, N. Freud, D. Sarrut, J.-M. Letang. Filtered backprojection proton CT reconstruction along most likely paths. Medical Physics, 2013, 40 (3), pp.031103. ⟨10.1118/1.4789589⟩. ⟨hal-00796949⟩
  • M. Gouzevitch. Jet physics at CMS. 27ème Rencontres de Physique de la Vallée d'Aoste, Feb 2013, La Thuile, France. pp.97-104, ⟨10.1393/ncc/i2014-11621-x⟩. ⟨in2p3-00967867⟩
  • N. Redon. Structure of the first excited states in large deformed rare-earth nuclei approaching the proton drip-line. Workshop AGATA@GANIL, Feb 2013, Caen, France. ⟨in2p3-00994738⟩
  • Guillaume Drieu La Rochelle. Higgs couplings as a probe of New Physics. The Toyama International Workshop on "Higgs as a Probe of New Physics 2013" (HPNP2013), Feb 2013, Toyama, Japan. ⟨in2p3-00826389⟩

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