Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Elisabeth Daguenet, Safa Louati, Anne-Sophie Wozny, Nicolas Vial, Mathilde Gras, et al.. Radiation-induced bystander and abscopal effects: important lessons from preclinical models. British Journal of Cancer, 2020, 123 (3), pp.339-348. ⟨10.1038/s41416-020-0942-3⟩. ⟨hal-02927729⟩
  • Chen-Hui Chan, Floriane Poignant, Michael Beuve, Elise Dumont, David Loffreda. Effect of the Ligand Binding Strength on the Morphology of Functionalized Gold Nanoparticles. Journal of Physical Chemistry Letters, 2020, pp.2717-2723. ⟨10.1021/acs.jpclett.0c00300⟩. ⟨hal-02519412⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Elliptic and triangular flow of (anti)deuterons in Pb-Pb collisions at \sqrt{s_{\mathrm{NN}}} = 5.02 TeV. Phys.Rev.C, 2020, 102 (5), pp.055203. ⟨10.1103/PhysRevC.102.055203⟩. ⟨hal-02870839⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Measurement of nuclear effects on \psi\rm{(2S)} production in p-Pb collisions at \sqrt{\textit{s}_{\rm NN}} = 8.16 TeV. JHEP, 2020, 07, pp.237. ⟨10.1007/JHEP07(2020)237⟩. ⟨hal-02527038⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Search for a common baryon source in high-multiplicity pp collisions at the LHC. Phys.Lett.B, 2020, 811, pp.135849. ⟨10.1016/j.physletb.2020.135849⟩. ⟨hal-02564584⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Jet-hadron correlations measured relative to the second order event plane in Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 2.76 TeV. Phys.Rev.C, 2020, 101 (6), pp.064901. ⟨10.1103/PhysRevC.101.064901⟩. ⟨hal-02394743⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Measurements of inclusive jet spectra in pp and central Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 5.02 TeV. Phys.Rev.C, 2020, 101 (3), pp.034911. ⟨10.1103/PhysRevC.101.034911⟩. ⟨hal-02327851⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Multiplicity dependence of J/\psi production at midrapidity in pp collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2020, 810, pp.135758. ⟨10.1016/j.physletb.2020.135758⟩. ⟨hal-02863129⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Running of the top quark mass from proton-proton collisions at \sqrt{s} = 13TeV. Physics Letters B, 2020, 803, pp.135263. ⟨10.1016/j.physletb.2020.135263⟩. ⟨hal-02327849⟩
  • M. Siciliano, J.J. Valiente-Dobón, A. Goasduff, F. Nowacki, A.P. Zuker, et al.. Pairing-quadrupole interplay in the neutron-deficient tin nuclei: First lifetime measurements of low-lying states in ^{106,108} Sn. Physics Letters B, 2020, 806, pp.135474. ⟨10.1016/j.physletb.2020.135474⟩. ⟨hal-02144351⟩

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