Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • Judith Reindl, Ana Margarida Abrantes, Vidhula Ahire, Omid Azimzadeh, Sarah Baatout, et al.. Chapter 3. Molecular Radiation Biology. Springer nature. Radiobiology Textbook, Sarah Baatout, pp.83-189, 2023, 978-3-031-18809-1. ⟨10.1007/978-3-031-18810-7_3⟩. ⟨in2p3-04937597⟩
  • Emmanuel Grolleau, Julie Candiracci, Gaelle Lescuyer, David Barthelemy, Nazim Benzerdjeb, et al.. Circulating H3K27 Methylated Nucleosome Plasma Concentration: Synergistic Information with Circulating Tumor DNA Molecular Profiling. Biomolecules, 2023, 13 (8), pp.1255. ⟨10.3390/biom13081255⟩. ⟨hal-04549560⟩
  • Safa Louati. Formation différentielle des granules de stress dans les carcinomes épidermoïdes de la tête et du cou en réponse à l’irradiation photonique et par ions carbone. Cancer. Université Claude Bernard - Lyon I, 2023. Français. ⟨NNT : 2023LYO10075⟩. ⟨tel-05065542⟩
  • Yungan Tao, Xu-Shan Sun, Yoann Pointreau, Christophe Le Tourneau, Christian Sire, et al.. Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial. European Journal of Cancer, 2023, 183, pp.24-37. ⟨10.1016/j.ejca.2022.12.015⟩. ⟨hal-04002440⟩
  • David Barthelemy, Gaelle Lescuyer, Florence Geiguer, Emmanuel Grolleau, Arnaud Gauthier, et al.. Paired Comparison of Routine Molecular Screening of Patient Samples with Advanced Non-Small Cell Lung Cancer in Circulating Cell-Free DNA Using Three Targeted Assays. Cancers, 2023, 15 (5), pp.1574. ⟨10.3390/cancers15051574⟩. ⟨hal-04382917⟩
  • Dietrich Averbeck. Low-Dose Non-Targeted Effects and Mitochondrial Control. Int.J.Mol.Sc., 2023, 24 (14), pp.11460. ⟨10.3390/ijms241411460⟩. ⟨hal-04178836⟩
  • Anne-Sophie Wozny, Claire Rodriguez-Lafrasse. The ‘stealth-bomber’ paradigm for deciphering the tumour response to carbon-ion irradiation. British Journal of Cancer, 2023, 128, pp.1429-1438. ⟨10.1038/s41416-022-02117-6⟩. ⟨hal-03939645⟩
  • Hassan Abdoul-Carime, Janina Kopyra. Reactions in CCl4 films deposited onto a cold gold substrate induced by charge transfer vs (0–5) eV free electrons. Chem.Phys.Lett., 2023, 810, pp.140182. ⟨10.1016/j.cplett.2022.140182⟩. ⟨hal-03865746⟩
  • Janina Kopyra, Hassan Abdoul-Carime. Fragmentation of metal(II) bis(acetylacetonate) complexes induced by slow electrons. Beilstein J.Nanotechnol., 2023, 14, pp.980-987. ⟨10.3762/bjnano.14.81⟩. ⟨hal-04260493⟩
  • Nicolas Magné, Elisabeth Daguenet, Wafa Bouleftour, Laurine Conraux, Fabien Tinquaut, et al.. Impact of Radiation Therapy on Biological Parameters in Cancer Patients: Sub-analysis from the RIT Prospective Epidemiological Study. Cancer Investigation, 2023, 41 (2), pp.109-118. ⟨10.1080/07357907.2022.2139838⟩. ⟨hal-03865012⟩

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