Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M.-A. Chanrion, U. Jelen, A. Wittig, R. Engenhart-Cabillic, M. Beuve, et al.. Assessment of the influence of the the Local Effect Model input parameters on tumor control probability for prostate carbon ion therapy treatment plans. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838452⟩
  • R. Rescigno, Ch. Finck, D. Juliani, J. Baudot, D. Dauvergne, et al.. Simulation toolkit with CMOS detector in the framework of hadrontherapy. International Nuclear Physics Conference 2013, Jun 2013, Firenze, Italy. pp.10013, ⟨10.1051/epjconf/20146610013⟩. ⟨hal-01118474⟩
  • G. de France, A. Blanc, F. Drouet, M. Jentschel, U. Köster, et al.. Spectroscopy of neutron rich nuclei using cold neutron induced fission of actinide targets at the ILL : the EXILL campaign. International Nuclear Physics Conference - INPC2013, Jun 2013, Firenze, Italy. pp.02010, ⟨10.1051/epjconf/2014660102010⟩. ⟨in2p3-00831084⟩
  • F. Roellinghoff, A. Benilov, D. Dauvergne, G. Dedes, N. Freud, et al.. Optimization and comparison of two types of collimated camera for proton beam range monitoring. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838463⟩
  • G. Dedes, S. Rit, D. Dauvergne, N. Freud, J. Krimmer, et al.. Spatial resolution and electron density study for proton computed tomography (pCT), using a curved proton track reconstruction algorithm. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838489⟩
  • A. Bartolomé P., A. Mushkarenkov, J. Ahrens, J.R.M. Annand, H.-J. Arends, et al.. First measurement of the helicity dependence of 3He photoreactions in the Δ(1232)Δ(1232) resonance region. Physics Letters B, 2013, 723 (1-3), pp.71-77. ⟨10.1016/j.physletb.2013.04.057⟩. ⟨hal-00975799⟩
  • Raphaël Tieulent. Le détecteur VZERO, la physique muons présente et la préparation de son futur dans l'expérience ALICE au LHC. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2013. ⟨tel-00926345⟩
  • A. Blanc, G. de France, F. Drouet, M. Jentschel, U. Köster, et al.. Spectroscopy of neutron rich nuclei using cold neutron induced fission of actinide targets at the ILL: The EXILL campaign. Fifth International Workshop on Nuclear Fission and Fission-Product Spectroscopy, May 2013, Caen, France. pp.01001, ⟨10.1051/epjconf/20136201001⟩. ⟨in2p3-00919008⟩
  • D. Gorse-Pomonti, N. L. Do, N. Bérerd, N. Moncoffre, G. Baldinozzi. Ellipsometric study of the oxides formed on titanium and zirconium under argon irradiation. European Materials Research Society (EMRS) Spring meeting, May 2013, Strasbourg, France. ⟨in2p3-01018449⟩
  • B. Marchand, N. Bérerd, Y. Pipon, N. Moncoffre, M. Toulemonde, et al.. Role of electronic excitations on xenon migration in UO2. European Materials Reserch Society (EMRS) Spring meeting, May 2013, Strasbourg, France. ⟨in2p3-01018441⟩

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