Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Manescu, H. Ladjal, Joseph Azencot, M. Beuve, B. Shariat. Biomechanical-based respiratory motion-compensation for 4D dose calculation during hadron therapy. 27th International Congress and Exhibition, Computer Assisted Radiology, Jun 2013, Heidelberg, Germany. pp.39-44, ⟨10.1007/s11548-013-0849-z⟩. ⟨hal-00850636⟩
  • J. Gascon, N. Bastidon. The EDELWEISS-III Project and the Rejection Performance of Its Cryogenic Germanium Detectors. 15th International Workshop on Low Temperature Detectors LTD15, Jun 2013, Passadena, CA, United States. pp.870-875, ⟨10.1007/s10909-014-1096-6⟩. ⟨in2p3-01011172⟩
  • M. Gherrab, N. Millard-Pinard, S. Gavarini, V. Garnier. Elaboration et caractérisation de carbures de titane nano et microstructurés. Journée scientifique de l'ARC Energies, Jun 2013, Lyon, France. ⟨in2p3-00979109⟩
  • J. Krimmer, L. Balleyguier, J. Baudot, S. Brons, L. Caponetto, et al.. Real-Time Online Monitoring of the Ion Range by Means of Prompt Secondary Radiations. 3rd International Conference On Advancements In Nuclear Instrumentation Measurement Methods And Their Applications (ANIMMA 2013), Jun 2013, Marseille, France. pp.1-8, ⟨10.1109/ANIMMA.2013.6728046⟩. ⟨hal-00873701⟩
  • M. Le Guillou, N. Toulhoat, Y. Pipon, N. Moncoffre, N. Bérerd, et al.. Thermal behavior of deuterium implanted into nuclear graphite studied by NRA. 21st International Conference on Ion Beam Analysis (IBA - 2013), Jun 2013, Seattle, WA, United States. ⟨10.1016/j.nimb.2014.02.036⟩. ⟨in2p3-00980435⟩
  • J. Jagielski, G. Gawlik, I. Jozwik-Biala, Gérard Panczer, N. Moncoffre, et al.. Luminescence analysis of damage accumulation; case study of calcium molybdate. 21st International Conference on Ion Beam Analysis (IBA - 2013), Jun 2013, Seattle, WA, United States. pp.60-62, ⟨10.1016/j.nimb.2014.02.030⟩. ⟨in2p3-00980437⟩
  • V. Sanglard. EDELWEISS-­‐II WIMP search at low energy. 9th International Conference on the Identification of Dark Matter (IDM 2012), Jun 2013, Chicago, United States. ⟨in2p3-01011179⟩
  • G. Silbermann, N. Moncoffre, N. Toulhoat, N. Bérerd, A. Perrat-Mabilon, et al.. Temperature effects on the behavior of carbon 14 in nuclear graphite. 21st International Conference on Ion Beam Analysis (IBA - 2013), Jun 2013, Seattle, WA, United States. ⟨10.1016/j.nimb.2014.02.040⟩. ⟨in2p3-00980436⟩
  • C. Girerd. Développements à l'IPNL. xTCA DAQ working group, Jun 2013, Marseille, France. ⟨in2p3-01019683⟩
  • G. Alphonse, D. Ardail, E. Armandy, M. Bajard, J. Balosso, et al.. 2012 Activity Report of the Regional Research Programme on Hadrontherapy for the ETOILE Center. [Research Report] Centre Etoile; Université Lyon 1 - Claude Bernard. 2013. ⟨hal-00840163⟩

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