Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Edoardo Carlesi, Yehuda Hoffman, Stefan Gottlöber, Noam I. Libeskind, Alexander Knebe, et al.. On the mass assembly history of the Local Group. Monthly Notices of the Royal Astronomical Society, 2020, 491 (2), pp.1531-1539. ⟨10.1093/mnras/stz3089⟩. ⟨hal-02447937⟩
    • E. Guillaume, E. Daguenet, C. Lahmamssi, M. Ben Mrad, O. Jmour, et al.. Facteurs de risque d’asthĂ©nie en cours de la radiothĂ©rapie des cancers du sein et de la prostate. Cancer/RadiothĂ©rapie, 2020, 24 (1), pp.15-20. ⟨10.1016/j.canrad.2019.09.005⟩. ⟨hal-02571531⟩
    • Yijung Kang, Young-Wook Lee, Young-Lo Kim, Chul Chung, Chang Hee Ree. Early-type Host Galaxies of Type Ia Supernovae. II. Evidence for Luminosity Evolution in Supernova Cosmology. The Astrophysical Journal, 2020, 889 (1), pp.8. ⟨10.3847/1538-4357/ab5afc⟩. ⟨hal-02440006⟩
    • Giacomo Cacciapaglia, Teng Ma, Shahram Vatani, Yongcheng Wu. Towards a fundamental safe theory of composite Higgs and Dark Matter. European Physical Journal C: Particles and Fields, 2020, 80 (11), pp.1088. ⟨10.1140/epjc/s10052-020-08648-7⟩. ⟨hal-01965345⟩
    • Floriane Poignant, Caterina Monini, Étienne Testa, MichaĂ«l Beuve. Influence of gold nanoparticles embedded in water on nanodosimetry for keV photon irradiation. Medical Physics, 2020, 48 (4), pp.1874-1883. ⟨10.1002/mp.14576⟩. ⟨hal-03001810⟩
    • W. B. Li, A. Belchior, M. Beuve, Y. Z. Chen, S. Di Maria, et al.. Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo simulation codes. Physica Medica European Journal of Medical Physics, 2020, 69, pp.147-163. ⟨10.1016/j.ejmp.2019.12.011⟩. ⟨hal-02452613⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Z-boson production in p-Pb collisions at \sqrt{s_{\mathrm{NN}}}=8.16 TeV and Pb-Pb collisions at \sqrt{s_{\mathrm{NN}}}=5.02 TeV. Journal of High Energy Physics, 2020, 09, pp.076. ⟨10.1007/JHEP09(2020)076⟩. ⟨hal-02863131⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Studies of J/\psi production at forward rapidity in Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 5.02 TeV. Journal of High Energy Physics, 2020, 02, pp.041. ⟨10.1007/JHEP02(2020)041⟩. ⟨hal-02317308⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. ϒ production in p–Pb collisions at \sqrt{s_{NN}}=8.16 TeV. Phys.Lett.B, 2020, 806, pp.135486. ⟨10.1016/j.physletb.2020.135486⟩. ⟨hal-02383444⟩
    • S. Acharya, D. Adamová, S.P. Adhya, A. Adler, J. Adolfsson, et al.. Measurement of \Lambda(1520) production in pp collisions at \sqrt{s} = 7 TeV and p-Pb collisions at \sqrt{s_{\rm{NN}}} = 5.02 TeV. European Physical Journal C: Particles and Fields, 2020, 80 (2), pp.160. ⟨10.1140/epjc/s10052-020-7687-2⟩. ⟨hal-02498393⟩

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