Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • I. Laktineh. Tracking in hadronic showers in the SDHCAL prototype using Hough Transform. 2013 International Workshop on Future Linear Colliders (LCWS13), Nov 2013, Tokyo, Japan. ⟨in2p3-00906136⟩
  • Julie Constanzo. Développement de la plateforme Radiograaff d'irradiation protons pour des études en radiobiologie.. Physique Nucléaire Expérimentale [nucl-ex]. Université Claude Bernard - Lyon I, 2013. Français. ⟨NNT : ⟩. ⟨tel-00977357⟩
  • S. Pirrone, G. Politi, M. La Commara, J.P. Wieleczko, E. de Filippo, et al.. Decay competition in IMF production in the collisions 78Kr+40Ca and 86Kr+48Ca at 10 AMeV. International Symposium Entrance Channel Effect on the Reaction Mechanism in Heavy Ion Collisions (ECHIC2013), Nov 2013, Messina, Italy. pp.012018, ⟨10.1088/1742-6596/515/1/012018⟩. ⟨in2p3-01026216⟩
  • K. Bennaceur. Density-independent effective interaction for mean-field and beyond mean-field calculations. Nuclear Structure and Astrophysical Applications, Nov 2013, Trento, Italy. ⟨in2p3-00978624⟩
  • A. Uras. Low mass dilepton production in pp, p-Pb and Pb-Pb collisions measured with ALICE at the LHC. 6th International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions (Hard Probes 2013), Nov 2013, Cape Town, South Africa. pp.218-223, ⟨10.1016/j.nuclphysa.2014.10.050⟩. ⟨in2p3-01018948⟩
  • H. Ladjal, B. Shariat, Joseph Azencot, M. Beuve. Appropriate Biomechanics and kinematics Modeling of the respiratory System: Human Diaphragm and Thorax. IEEE/RSJ International Conference on Intelligent Robots and Systems, Nov 2013, Tokyo, Japan. pp.2004-2009, ⟨10.1109/IROS.2013.6696623⟩. ⟨hal-00850623⟩
  • O. Stézowski. Geant4: a simulation toolkit. Ecole Internationale de Physique Subatomique EIPS, Nov 2013, Lyon, France. ⟨in2p3-01018629⟩
  • J. Constanzo. Développement de la plateforme Radiograaff d'irradiation protons pour des études en radiobiologie. 2013. ⟨hal-00949679⟩
  • V. N. Ivanchenko, S. Incerti, J. Allison, A. Bagulya, J.M.C. Brown, et al.. Geant4 electromagnetic physics: improving simulation performance and accuracy. Joint International Conference on Supercomputing in Nuclear Applications and Monte Carlo, Oct 2013, Paris, France. 2014. ⟨in2p3-00978306⟩
  • Denis Dauvergne, Etienne Testa. Status Review of Ion Therapy Monitoring by Prompt Secondary Radiation. 2013 IEEE Nuclear Science Symposium & Medical Imaging Conference & Workshop on Room-Temperature semiconductor X-rays and Gamma-rays detectors, Oct 2013, Séoul, South Korea. ⟨hal-00880715⟩

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