Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • C. Teyssier, R. Fillol, H. Abdoul-Carime, B. Farizon, M. Farizon, et al.. A novel "Correlated Ion and Neutral Time Of Flight" Method: event-by-event detection of neutral and charged fragments in Collision Induced Dissociation (CID) of mass selected ions. Review of Scientific Instruments, 2014, 85, pp.015118. ⟨10.1063/1.4863015⟩. ⟨in2p3-00932141⟩
  • B. Abelev, Laurent Aphecetche, Y.W. Baek, N. Bastid, Guillaume Batigne, et al.. Centrality, rapidity and transverse momentum dependence of J/Psi suppression in Pb-Pb collisions at sqrt(sNN)=2.76TeV. Physics Letters B, 2014, 734, pp.314-327. ⟨10.1016/j.physletb.2014.05.064⟩. ⟨in2p3-00879452⟩
  • B. Abelev, Laurent Aphecetche, Guillaume Batigne, I. Belikov, C. Cheshkov, et al.. Event-by-event mean p_{\rm T} fluctuations in pp and Pb-Pb collisions at the LHC. European Physical Journal C: Particles and Fields, 2014, 74, pp.3077. ⟨10.1140/epjc/s10052-014-3077-y⟩. ⟨in2p3-01030781⟩
  • G. Cacciapaglia. A passion for particles. Conference in honour of Riccardo Barbieri, Dec 2013, Pise, Italy. ⟨in2p3-00980210⟩
  • Antoine Blondel. Effets de la tempĂ©rature et de l’irradiation sur le comportement du chlore 37 dans le graphite nuclĂ©aire : consĂ©quences sur la mobilitĂ© du chlore 36 dans les graphites irradiĂ©s. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© Claude Bernard - Lyon I, 2013. Français. ⟨NNT : 2013LYO10323⟩. ⟨tel-01202855⟩
  • Mehdi Gherrab. Étude du carbure de titane nano- et micro-structurĂ© : Ă©laboration et comportement en conditions extrĂŞmes d'irradiation aux ions 40Ar+. Autre [cond-mat.other]. UniversitĂ© Claude Bernard - Lyon I, 2013. Français. ⟨NNT : 2013LYO10305⟩. ⟨tel-00958369v2⟩
  • Victor Buridon. Application de la spectromĂ©trie de masse COINTOF Ă  l'Ă©tude de la dissociation de petits agrĂ©gats d'eau protonĂ©s par collision sur un atome d'argon : dĂ©veloppement d'une cible de nano-gouttes de gaz rare. AgrĂ©gats MolĂ©culaires et Atomiques [physics.atm-clus]. UniversitĂ© Claude Bernard - Lyon I, 2013. Français. ⟨NNT : 2013LYO10262⟩. ⟨tel-01825570⟩
  • J. Marteau. Latest results in muon radiography applied to volcanology. International Symposium on EcoTopia Science (ISETS 2013), Dec 2013, Nagoya, Japan. ⟨in2p3-01019535⟩
  • Sacha Davidson. The axion vs the WIMP. XIX IFT Xmas Workshop, Dec 2013, Madrid, Spain. ⟨in2p3-00976086⟩
  • Sacha Davidson. Baryogenesis and dark matter. New from the Dark, Dec 2013, Montpellier, France. ⟨in2p3-00976094⟩

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